| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Recent progress in the human genome project prompted us to re-evaluate additional target genes in cancers. In this study, we tested whether DTL and TMEM206, located at previously reported 1q32-q41 amplicon, acts as a cancer-promoting gene in esophageal squamous cell carcinoma(ESCC. Overexpression of DTL and/or TMEM206 protein was frequently detected in primary ESCCs, and significantly correlated with the status of recurrence. Patients with DTL and/or TMEM206-overexpressing tumors had a worse overall survival than those with non-expressing tumors, and DTL and/or TMEM206 was independent prognosticator in the multivariate analysis. Knockdown of DTL or TMEM206 inhibited and ectopic overexpression of DTL and/or TMEM206 promoted the growth of ESCC cells. These findings suggest that DTL and TMEM206 plays an important role in tumor cell growth, and highlight its usefulness as a prognosticator and potential therapeutic target in ESCC.
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