Identification of novel oncogenes, as targets for amplification in esophageal squamous cell carcinoma
| Project/Area Number |
24791441
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
KOMATSU Shuhei 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40578978)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 増幅遺伝子 / 癌遺伝子 / 食道癌 / 胃癌 / 遊離核酸 / 予後因子 / 分子生物学 / アレイCGH / 治療標的遺伝子 / バイオマーカー / 消化器癌 / 消化器外科学 / 食道外科学 / 分子標的 |
|---|
| Outline of Final Research Achievements |
Recent progress in the human genome project prompted us to re-evaluate additional target genes in cancers. In this study, we tested whether DTL and TMEM206, located at previously reported 1q32-q41 amplicon, acts as a cancer-promoting gene in esophageal squamous cell carcinoma(ESCC. Overexpression of DTL and/or TMEM206 protein was frequently detected in primary ESCCs, and significantly correlated with the status of recurrence. Patients with DTL and/or TMEM206-overexpressing tumors had a worse overall survival than those with non-expressing tumors, and DTL and/or TMEM206 was independent prognosticator in the multivariate analysis. Knockdown of DTL or TMEM206 inhibited and ectopic overexpression of DTL and/or TMEM206 promoted the growth of ESCC cells. These findings suggest that DTL and TMEM206 plays an important role in tumor cell growth, and highlight its usefulness as a prognosticator and potential therapeutic target in ESCC.
|
Report
(4 results)
Research Products
(25 results)
-
-
-
-
[Journal Article] Overexpression of SMYD2 contributes to malignant outcome in gastric cancer2014
Author(s)
Komatsu S, Ichikawa D, Hirajima S, Nagata H, Nishimura Y, Kawaguchi T, Miyamae M, Okajima W, Ohashi T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Imoto I, Inazawa J, Otsuji E
-
Journal Title
Br J Cancer
Volume: 112
Issue: 2
Pages: 357-64
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
