| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
High Mobility Group Box Protein (HMGB1) is protein in the nuclei, but it is released outside a cell under the presence of severe inflammation, and it is widely known that it play big roles in the onset of the DIC. On the other hand, it is reported that it participate in the progression and metastasis of cancer, but the bioactivity is unknown enough. The principal aim of this study was to elucidate the expression of High-Mobility Group Box1 in the human pancreatic cancer and the influence of local anti-cancer immunity, and to develop therapeutic strategy effective for pancreatic cancer. But the experiment did not advance according to assumption and we can not achieve an original purpose.
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