| Project/Area Number |
24791446
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IIDA Takeshi 和歌山県立医科大学, 医学部, 学内助教 (30453187)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 胃癌 / 腫瘍 / IL-17 / 腹腔 / 癌 / サイトカイン |
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| Research Abstract |
We investigated the expression level of IL-17 mRNA in peritoneal lavage with gastric cancer patients and assessed the association of its expression with clinicopathological parameters and prognosis. IL-17 mRNA expression was associated with the depth of the invasion.The survival curves in patients who underwent curative resection showing high expression of IL-17 mRNA were significantly better than that in patients showing low expression of IL-17 mRNA. In a multivariate analysis, IL-17 mRNA-low expression in peritoneal lavage and tumor size were independent significant predictive factors for prognosis.IL-17 mRNA expression in peritoneal lavage detected by real-time RT-PCR is a reliable prognostic factor in patients with curative resection in gastric cancer. Low IL-17 gene expression in the peritoneal cavity may correlate with cancer development in the peritoneal cavity in patients with gastric cancer.
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