Translational research of the gene therapy for pancreatic cancer

• Project/Area Number: 24791448
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Jikei University School of Medicine
• Principal Investigator: FURUKAWA Kenei 東京慈恵会医科大学, 医学部, 助教 (80624973)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: FUT-175 / NF-κB / Gemcitabine / TNF-α / ｱﾃﾞﾉｳｲﾙｽﾍﾞｸﾀｰ / 膵癌 / メシル酸ナファモスタット / 塩酸ゲムシタビン / アデノウイルスベクター / 膵臓癌 / ゲムシタビン

Research Abstract

Pancreatic cancer is one of a most fatal digestive cancer. Though the only curative treatment of pancreatic cancer is the surgical resection, most patients are not amenable to resection because they are already advanced when diagnosed.
We examined that whether the tumor necrosis factor-alpha gene delivery could induce the progression of pancreatic cancer. We demonstrate that TNF-alpha gene delivery using adenovirus vector suppressed cancer growth in vivo and vitro.

Research Products

• [Journal Article] Inhibition of nuclear factor kappa-B enhances the antitumor effect of combination treatment with tumor necrosis factor-alpha gene therapy and gemcitabine for pancreatic cancer in mice. (2013)
  • Author(s): Yuki Fujiwara, Hiroaki Shiba, Ryota Iwase, Koichiro Haruki, Kenei Furukawa, Tadashi Uwagawa, Takeyuki Misawa, Toya Ohashi, Katsuhiko Yanaga
  • Journal Title: Journal of the American College of Surgeons Volume: 216 Issue: 2 Pages: 320-332
  • DOI: 10.1016/j.jamcollsurg.2012.09.016
  • Peer Reviewed
• [Presentation] Inhibition of NF-κB enhances the anti-tumor effect of combination treatment with tumor necrosis factor-alpha (TNF-α) gene therapy and gemcitabine for pancreatic cancer in mice (2012)
  • Author(s): Fujiwara Y, Shiba H, Iwase R, Haruki K, Furukawa K, Uwagawa T, Misawa T, Ohashi T, Yanaga K
  • Organizer: 98 th American college of surgeons annual clinical congress
  • Place of Presentation: Chicago, USA
• [Presentation] 膵臓癌におけるメシル酸ナファモスタット併用TNF-alpha遺伝子導入および塩酸ジェムシタビン療法の抗腫瘍効果の検討 (2012)
  • Author(s): 藤原佑樹, 矢永勝彦, 岩瀬亮太, 春木孝一郎, 古川賢英, 飯田智憲, 柴 浩明, 宇和川 匡, 三澤健之, 大橋十也, 大木隆生
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉
• [Presentation] Inhibition of nuclear factor kappa-B enhances the antitumor effect of combination treatment with tumor necrosis factor-alpha (TNF-α) gene therapy and gemcitabine for pancreatic cancer in mice. (2012)
  • Author(s): Yuki Fujiwara
  • Organizer: 98th American college of surgeons annual clinical congress
  • Place of Presentation: Chicgo, USA