Research Project
Grant-in-Aid for Young Scientists (B)
By combining in silico and experimental approaches, we identified miR-34b and miR-126 to be silenced by DNA methylation in non-small cell lung cancer (NSCLC). The DNA methylation of miR-34b was significantly associated with lympatic invation in primary NSCLC. We also found that miR-139 was frequently suppressed by histone methylation of its host gene PDE2A in NSCLC. We also found that decreased miR-139 expression was significantly associated with distant lymph node metastasis and histological invasiveness in primary NSCLC. These results suggest that epigentic silencing of miRNAs may contribute to malignant phenotype of NSCLC.
All 2014 2013 2012
All Journal Article (24 results) (of which Peer Reviewed: 23 results, Open Access: 1 results) Presentation (15 results)
Cancer Sci
Volume: 105 Issue: 9 Pages: 1135-1141
10.1111/cas.12472
J Bronchology Interv Pulmonol.
Volume: 21(2) Issue: 2 Pages: 113-116
10.1097/lbr.0000000000000051
Korean J Thorac Cardiovasc Surg.
Volume: 47(6) Issue: 6 Pages: 563-565
10.5090/kjtcs.2014.47.6.563
Annals of Thoracic and Cardiovascular Surgery
Volume: 20 Issue: Supplement Pages: 539-541
10.5761/atcs.cr.12.02102
130003377823
Ann Thorac Surg.
Volume: 98(6) Issue: 6 Pages: 2202-2204
10.1016/j.athoracsur.2014.01.084
Surg Today.
気管支学
Volume: 36(2) Pages: 138-141
110009807526
胸部外科
Volume: 67(6) Pages: 459-462
Volume: 67(11) Pages: 963-966
Surgery Today
Volume: - Issue: 3 Pages: 499-504
10.1007/s00595-013-0562-0
Volume: Feb 15
Asian Cardiovascular and Thoracic Annals
Volume: 21 Issue: 1 Pages: 93-96
10.1177/0218492312450020
European journal of cardio-thoracicsurgery.
Volume: 43(5) Issue: 5 Pages: 925-932
10.1093/ejcts/ezs467
Transplantation Proceedings
Volume: - Issue: 5 Pages: 1797-1801
10.1016/j.transproceed.2012.11.024
Volume: 21 Issue: 5 Pages: 582-587
10.1177/0218492312467174
呼吸と循環
Volume: 61 Pages: 970-974
40019809975
日本臨床外科学会雑誌
Volume: 74 Pages: 2116-2118
10031203071
Volume: 66 Pages: 855-857
臨床呼吸生理
Volume: 45 Pages: 35-37
Volume: 66 Pages: 563-565
European Journal of Cardiothoracic Surgery
Volume: 42
Volume: 41 Issue: 3 Pages: 623-627
10.1093/ejcts/ezr026
Volume: 65 Pages: 1127-1130
40019497437
Volume: 65 Pages: 1038-1043
40019467093