microRNAs biomarkers for non-small cell lung cancer
| Project/Area Number |
24791455
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SANO Atsushi 東京大学, 医学部附属病院, 登録研究員 (20569834)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腫瘍外科学 / 肺癌 / マイクロRNA / エピジェネティクス / DNAメチル化 / ヒストン修飾 / ＤＮＡメチル化 / マイクロＲＮＡ |
|---|
| Outline of Final Research Achievements |
By combining in silico and experimental approaches, we identified miR-34b and miR-126 to be silenced by DNA methylation in non-small cell lung cancer (NSCLC). The DNA methylation of miR-34b was significantly associated with lympatic invation in primary NSCLC. We also found that miR-139 was frequently suppressed by histone methylation of its host gene PDE2A in NSCLC. We also found that decreased miR-139 expression was significantly associated with distant lymph node metastasis and histological invasiveness in primary NSCLC. These results suggest that epigentic silencing of miRNAs may contribute to malignant phenotype of NSCLC.
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Report
(4 results)
Research Products
(39 results)
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[Presentation] VIRTUAL BRONCHOSCOPY USING OsiriX.2014
Author(s)
Sano A, Tsuchiya T, Kawashima M, Tashiro K, Hoshino M, Hara H, Fukuda T.
Organizer
18th World Congress of Bronchology and Interventional Pulmonology.
Place of Presentation
京都
Year and Date
2014-04-14
Related Report
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[Presentation] Loss of PABPN1 and alternative polyadenylation yield poor prognosis in non-small cell lung cancer.2014
Author(s)
Ichinose J, Watanabe K, Sano A, Nagase T, Nakajima J, Fukayama M, Yatomi Y, Ohishi N, Takai D.
Organizer
3rd AACR-IASLC Joint Conference on the Molecular Origins of Lung Cancer
Place of Presentation
Sandiego, CA, USA.
Related Report
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