| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Aortic aneurysm is a silent but life-threaterning disease associated with aging and atherosclerosis. Surgery for aortic aneurysm have high morbidity and mortality. In this study, we developed novel surgical tool for aortic surgery that was composed biodegradable polymer and peptide which has high affinity of fibroblast to reduce aortic remodeling after surgery. This material will be used for reinforcement of anastomosis or wrapping in aortic surgery same as felt. We tried to create appropriate material which has elastic mechanical property. The peptide was attached to the material by use of cross linker (sulfa-SANPHA) technique. The peptide liked material was significantly increased attached cells compared to non-peptide material. This material was implanted canine descending aorta with aortic anastomosis. Pseudo aneurysm or/and aortic dissection were not fund in anastomosis site, however, infiltration of the cells were not significantly increased in material with peptide.
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