The mechanism of ischemia reperfusion injury and abrogation of lung allograft acceptance after lung transplantation

• Project/Area Number: 24791461
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: Okayama University
• Principal Investigator: SUGIMOTO Seiichiro 岡山大学, 大学病院, 助教 (40570148)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肺移植 / 虚血再灌流障害 / 急性拒絶反応 / 免疫寛容

Research Abstract

Outcomes after lung transplantation remain significantly worse than those after transplantation of other solid organs. Ischemia reperfusion injury is the leading cause for early morbidity and mortality after lung transplantation and has also been shown to be a risk factor for chronic lung rejection demonstrating its long-term effect on allografts. In this study, we examined the mechanism of ischemia reperfusion injury and abrogation of lung allograft acceptance after lung transplantation.

Research Products

• [Presentation] MAPK/ERK pathway activation leads to severe ischemia-reperfusion-induced lung injury (2013)
  • Author(s): Okada M, Yamane M, Sugimoto S, 他
  • Organizer: The International Society for Heart and Lung Transplantation 33th Annual Meeting and Scientific Sessions
  • Place of Presentation: モントリオール(カナダ)
  • Year and Date: 2013-04-27
• [Presentation] 肺細胞傷害後に放出される細胞外ATP による肺移植後のTh17 依存性拒絶反応 (2012)
  • Author(s): 杉本誠一郎, 他
  • Organizer: 第65回日本胸部外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-10-18
• [Presentation] MAPK/ERK pathway activation leads to ischemia-reperfusion-induced lung injury (2012)
  • Author(s): Okada M, Yamane M, Sugimoto S, 他
  • Organizer: The 24th International Congress of The Transplantation Society
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2012-07-19
• [Presentation] Release of ATP by injured pulmonary cells triggers Th17 dependent lung allograft rejection (2012)
  • Author(s): Sugimoto S, 他
  • Organizer: The International Society for Heart and Lung Transplantation 32th Annual Meeting and Scientific Sessions
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2012-04-18
• [Presentation] MAPK/ERK pathway activation leads to severe ischemia-reperfusion-induced lung injury
  • Author(s): Okada M、Yamane M、Sugimoto S、他
  • Organizer: The International Society for Heart and Lung Transplantation 33th Annual Meeting and Scientific Sessions
  • Place of Presentation: モントリオール（カナダ）