Explication of the role of the Bone Morphogenetic Protein (BMP) in lung cancer progression
Project/Area Number |
24791466
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Thoracic surgery
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Research Institution | Kagoshima University |
Principal Investigator |
AOKI Masaya 鹿児島大学, 医歯(薬)学総合研究科, 助教 (50624996)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | BMP-7と予後との関連 / BMP-7とリンパ節転移との関連 / BMP-7とpSmad1/5/8との予後との関連 / 国際学会報告 / 国内学会報告 / 英語論文 / 非小細胞肺癌 / 骨形成性蛋白 / BMP7 / リン酸化Smad |
Outline of Final Research Achievements |
We evaluated expression of BMP-7 in non-small cell lung cancer (NSCLC) tissue by immunohistochemistry, and analyzed correlations between expression of BMP-7 and clinicopathological factors and prognosis. The results of this study showed that expression of BMP-7 in NSCLC was correlated with clinicopathological factors and poorer prognosis. We reported these results both in national and international academic meetings and submitted to English journals. Moreover, we evaluated and analyzed expression of p-Smad1/5/8, which is a downstream molecule of the BMP/Smad signaling pathway, in the same way. The results of this study demonstrated that, although expression of p-Smad1/5/8 in NSCLC was not correlated with clinicopathological factors, overexpression of both BMP-7 and p-Smad1/5/8 was correlated with better prognosis. We reported these results in a national academic meeting.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] 【胸腔鏡を用いた縦隔疾患の手術適応とその手技】 胸腔鏡のみのアプローチ 重症筋無力症に対する胸腔鏡下拡大胸腺摘出術2012
Author(s)
青木雅也, 永田俊行, 梅原 正, 鈴木聡一, 原田亜矢, 脇田和博, 大塚綱志, 狩集弘太, 酒瀬川浩一, 中村好宏, 佐藤雅美
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Journal Title
胸部外科
Volume: 65(11)
Pages: 960-963
Related Report
Peer Reviewed
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[Presentation] A Tumor Excision Case of Castleman Disease in Pulmonary Hilum2014
Author(s)
Aoki M, Otsuka T, Wakida K, Umehara T, Harada A, Kamimura G, Watanabe Y. Nagata T, Yokomakura N, Kariatsumari K, Sakasegawa K, Nakamura Y, Sato M
Organizer
18th WCBIP
Place of Presentation
Japan/Kyoto
Year and Date
2014-04-14 – 2014-04-15
Related Report
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[Presentation] 完全切除肺癌におけるBMP7発現の臨床病理学的意義
Author(s)
青木雅也, 前田光喜, 大塚綱志, 横枕直哉, 柳 正和, 梅原 正, 鈴木聡一, 原田亜矢, 永田俊行, 狩集弘太, 酒瀬川浩一, 中村好宏, 夏越祥次, 佐藤雅美
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡
Related Report
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[Presentation] Expression of BMP-7 in non-small cell lung cancer and its clinical significance
Author(s)
Masaya Aoki, Tsunayuki Otsuka, Naoya Yokomakura, Masakazu Yanagi, Aya Harada, Go Kamimura, Kazuhiro Wakida, Yui Watanabe, Toshiyuki Nagata, Kota Kariatsumari, Yoshihiro Nakamura, Masami Sato
Organizer
15th World conference on Lung Cancer
Place of Presentation
シドニー(オーストラリア)
Related Report
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[Presentation] 肺癌進行におけるBMP-7発現の重要性
Author(s)
青木雅也, 梅原 正, 鈴木聡一, 原田亜矢, 脇田和博, 渡辺有為, 永田俊行, 酒瀬川浩一, 中村好宏, 佐藤雅美:
Organizer
第45回胸部外科学会九州地方会総会
Place of Presentation
佐世保市
Related Report
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[Presentation] 肺癌におけるBMP-7発現の臨床病理学的研究
Author(s)
青木雅也, 梅原 正, 鈴木聡一, 原田亜矢, 渡辺有為, 永田俊行, 大塚綱志, 狩集弘太, 酒瀬川浩一, 中村好宏, 脇田和博, 横枕直哉, 柳 正和, 夏越祥次, 佐藤雅美
Organizer
第65回日本胸部外科学会定期学術集会
Place of Presentation
福岡市
Related Report
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[Presentation] 肺癌進行に対するBMP-7の臨床病理学的重要性
Author(s)
青木雅也, 梅原 正, 鈴木聡一, 原田亜矢, 渡辺有為, 永田俊行, 大塚綱志, 狩集弘太, 酒瀬川浩一, 中村好宏, 脇田和博, 横枕直哉, 柳 正和, 佐藤雅美
Organizer
第53回日本肺癌学会総会
Place of Presentation
岡山市
Related Report