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Molecular analysis of lung cancer stem cell related gene, SMCP

Research Project

Project/Area Number 24791467
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Thoracic surgery
Research InstitutionSapporo Medical University

Principal Investigator

TAKAHASHI Akari  札幌医科大学, 医学部, 研究員 (80457697)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺がん / がん幹細胞 / SMCP / 腫瘍起始能 / 造腫瘍
Outline of Final Research Achievements

We isolated lung cancer stem-like cells(CSCs)/cancer-initiating cells(CICs) by side population assay. Transcriptome anslysis revealed that a novel cancer-testis gene SMCP is preferentially expressed in lung CSCs/CICs. Gene overexpression and gene knockdown assay using siRNAs revealed that SMCP has a role in the tumorigenicity of lung CSCs/CICs. These observations indicate that novel cancer testis gene SMCP might be a promising target for CSC/CIC-targeting therapy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013 2012 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (4 results)

  • [Journal Article] Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class I Molecule via Oxidative Folding2015

    • Author(s)
      Kukita K, Tamura Y, Tanaka T, Kajiwara T, Kutomi G, Saito K, Okuya K, Takaya A, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Furuhata T, Hirata K, Sato N.
    • Journal Title

      J Immunol.

      Volume: Epub

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells2015

    • Author(s)
      Tsutomu Tanaka, Koichi Okuya, Goro Kutomi, Akari Takaya, Toshimitsu Kajiwara, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Koichi Hirata, Yoshiharu Okamoto, Noriyuki Sato, Yasuaki Tamura
    • Journal Title

      Cancer Science

      Volume: 106 Issue: 1 Pages: 18-24

    • DOI

      10.1111/cas.12570

    • NAID

      120005593448

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A*2402 transgenic mice.2015

    • Author(s)
      Kasamatsu J, Takahashi S, Azuma M, Matsumoto M, Morii-Sakai A, Imamura M, Teshima T, Takahashi A, Hirohashi Y, Torigoe T, Sato N, Seya T.
    • Journal Title

      Immunobiology

      Volume: 220 Issue: 1 Pages: 74-82

    • DOI

      10.1016/j.imbio.2014.08.017

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells.2014

    • Author(s)
      Morita R, Nishizawa S, Torigoe T, Takahashi A, Tamura Y, Tsukahara T, Kanaseki T, Sokolovskaya A, Kochin V, Kondo T, Hashino S, Asaka M, Hara I, Hirohashi Y, Sato N.
    • Journal Title

      Cancer Sci

      Volume: 105 Issue: 4 Pages: 389-395

    • DOI

      10.1111/cas.12362

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.2013

    • Author(s)
      Takahashi A, Hirohashi Y, Torigoe T, Tamura Y, Tsukahara T, Kanaseki T, Kochin V, Saijo H, Kubo T, Nakatsugawa M, Asanuma H, Hasegawa T, Kondo T, Sato N.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e69095-e69095

    • DOI

      10.1371/journal.pone.0069095

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population.2013

    • Author(s)
      Yasuda K, Torigoe T, Morita R, Kuroda T, Takahashi A, Matsuzaki J, Kochin V, Asanuma H, Hasegawa T, Saito T, Hirohashi Y, Sato N.
    • Journal Title

      PLoS One

      Volume: 8(8) Issue: 8 Pages: e68187-e68187

    • DOI

      10.1371/journal.pone.0068187

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.2013

    • Author(s)
      Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Fujino J, Tamura Y, Tsukahara T, Kanaseki T, Kobayashi J, Sasaki T, Takahashi A, Nakamori K, Yamaguchi A, Hiratsuka H, Sato N.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 439 Issue: 1 Pages: 96-102

    • DOI

      10.1016/j.bbrc.2013.08.021

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] AIDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and AIDH1 high expression is associated with poor prognosis.2013

    • Author(s)
      Kuroda T, Hirohashi Y, Torigoe T, Yasuda K, Takahashi A, Asanuma H, Morita R, Mariya T, Asano T, Mizuuchi M, Saito T, Sato N.
    • Journal Title

      PLoS One

      Volume: 8(6) Issue: 6 Pages: e65158-e65158

    • DOI

      10.1371/journal.pone.0065158

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preferential expression of cancer/testis genes in cancer stem-like cells : proposal of a novel sub-category, cancer/testis/stem gene.2013

    • Author(s)
      Yamada R, Takahashi A, Torigoe T, Morita R, Tamura Y, Tsukahara T, Kanaseki T, Kubo T, Watarai K, Kondo T, Hirohashi Y, Sato N.
    • Journal Title

      Tissue Antigens.

      Volume: 81(6) Issue: 6 Pages: 428-34

    • DOI

      10.1111/tan.12113

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor.2013

    • Author(s)
      Nishida S, Hirohashi Y, Torigoe T, Inoue R, Kitamura H, Tanaka T, Takahashi A, Asanuma H, Masumori N, Tsukamoto T, Sato N.
    • Journal Title

      Cancer Sci

      Volume: 104 Issue: 4 Pages: 431-6

    • DOI

      10.1111/cas.12104

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression and function of FERMT genes in colon carcinoma cells2013

    • Author(s)
      Kiriyama K, Hirohashi Y, Torigoe T, Kubo T, Tamura Y, Kanaseki T, Takahashi A, et al.
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 167-73

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] DNA methyltransferase 1 is essential for initiation of the colon cancers2013

    • Author(s)
      Morita R,Hirohashi Y,Suzuki H, et al
    • Journal Title

      Experimental and Molecular Pathology

      Volume: 94 Issue: 2 Pages: 322-329

    • DOI

      10.1016/j.yexmp.2012.10.004

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes2012

    • Author(s)
      Takahashi A, Torigoe T, Tamura Y, Kanaseki T, Tsukahara T, Sasaki Y, Kameshima H, Tsuruma T, Hirata K, Tokino T, Hirohashi Y, Sato N
    • Journal Title

      Cell Stress Chaperones

      Volume: 17 Issue: 6 Pages: 757-763

    • DOI

      10.1007/s12192-012-0348-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Variant form of SMCP increases tumor initiation capacity of the stem cell population of lung adenocarcinoma cells2013

    • Author(s)
      Takahashi A, Torigoe T, Hirohashi Y, Tamura Y, Tsukahara T, Kanaseki T, Saijo H, Asanuma H, Sato N
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of the naturally processed peptide derived from FAM83B that is specifically expressed in cancer initiating cells2013

    • Author(s)
      Takahashi A, Kochin V, Kanaseki T, Hirohashi Y, Kawami S, Suzuki Y, Torigoe T, Sato N
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Research-status Report
  • [Presentation] Single cell cloning of cancer stem cells revealed distinct plasticity among cancer cells

    • Author(s)
      髙橋 あかり
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Moderate heat treatment enhances activities of human cytotoxic T lymphocytes

    • Author(s)
      髙橋 あかり
    • Organizer
      IHCO&JCTM(The 11th International Congress of Hyperthermic Oncology (ICHO) & The 29th Japanese Congress of Thermal Medicine (JCTM)合同大会)
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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