Next generation endoscope(complex type optical fiber) treatment for malignant pleural mesothelioma

• Project/Area Number: 24791473
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所)
• Principal Investigator: IMAI Kentaro 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, その他 (30408140)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 悪性胸膜中皮腫 / 光線力学的治療 / 複合型光ファイバー

Research Abstract

Malignant pleural mesothelioma is a disease with poor prognosis. Clinical trials have been enforced as multidisciplinary treatment surgery, chemotherapy, and radiation therapy, but it is not a standard treatment in Japan has been suggested. As a new therapeutic strategy, we verified using pigs as to whether or not obtained a sufficient antitumor effect minimum portion of the costophrenic angle or the like by using a small diameter fiber electrode photodynamic therapy is a local therapy I was decided. The result is that there was no impact on intra-abdominal organs and lungs no major side effects, it is a procedure that can be done with relative safety has been confirmed. In addition, it seemed anti-tumor effect was observed the same effect with conventional fiber, and can expect a great deal as one of the multidisciplinary treatment of malignant pleural mesothelioma in the future.

Research Products

• [Journal Article] Pneumothorax caused by costal exostosis (2014)
  • Author(s): Imai K, Suga Y, Nagatsuka Y, Usuda J, Ohira T, Kato H, Ikeda N
  • Journal Title: Ann Thorac Cardiovasc Surg Volume: 20(2) Pages: 161-4
  • NAID: 130002583843
• [Journal Article] Cavernous hemangioma of the first rib (2013)
  • Author(s): Imai K, Saji H, Ikeda N
  • Journal Title: Asian Cardiovasc Thorac Ann Volume: 21(4) Pages: 488-9
• [Presentation] 末梢肺病変に対する赤色光を用いた新たな手術支援法の開発 (2012)
  • Author(s): 臼田 実男 今井健太郎, 石角太一郎, 工藤 勇人, 古本 秀行, 佐治 久, 垣花 昌俊, 梶原 直央, 大平 達夫, 池田 徳彦
  • Organizer: 第65回日本胸部外科定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-10-20
• [Presentation] 末梢肺野病変に対する新たな内視鏡治療法の開発 (2012)
  • Author(s): 臼田 実男, 今井健太郎, 石角太一郎, 工藤 勇人, 本多 英俊, 垣花 昌俊, 佐治 久, 梶原 直央, 大平 達夫, 池田徳彦
  • Organizer: 第35回日本呼吸器内視鏡学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-31
• [Presentation] 中心型早期肺癌に対する光線力学的治療の現況 (2012)
  • Author(s): 工藤 勇人, 臼田 実男, 本多 英俊, 石角太一郎, 今井健太郎, 垣花 昌俊, 佐治久, 梶原 直央, 大平 達夫, 池田 徳彦
  • Organizer: 第35回日本呼吸器内視鏡学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-30
• [Presentation] 小型末梢肺癌に対する次世代型診断・治療装置の開発における医工連携の試み (2012)
  • Author(s): 臼田実男, 石角太一郎, 今井健太郎, 本多 英俊, 佐治 久, 垣花 昌俊, 梶原 直央, 大平達夫, 池田 徳彦
  • Organizer: 第29回日本呼吸器外科学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2012-05-17
• [Presentation] 小型肺腺癌に対する新たな治療戦略 (2012)
  • Author(s): 臼田 実男. 石角太一郎, 一ノ瀬修二, 今井健太郎, 佐治 久, 垣花 昌俊, 本多 英俊, 梶原 直央, 大平 達夫, 池田 徳彦
  • Organizer: 第112回日本外科学会定期学術集会
  • Year and Date: 2012-04-14
• [Presentation] Photodynamic Therapy Using NPe6 for Bronchogenic Carcinomas in Central Airways
  • Author(s): Kudo Y, Honda H, Saji H, Usuda J, Imai K, Kakihana M, Kajiwara N, Ikeda N, Ishizumi T, Ohira T
• [Presentation] The new interventional technique by photodynamic therapy using composite-type optical fiberscope of 1.0 mm in diameter for peripheral parenchymal lesion
  • Author(s): Furumoto H, Maehara S, Kudo Y, Imai K, Ohtani K, Usuda J, Kakihana M, Kajiwara N, Ohira T, Ikeda N