Development for a cancer therapy using anti-aging gene

• Project/Area Number: 24791474
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: Tokyo Medical University
• Principal Investigator: KUDO Yujin 東京医科大学, 医学部, 臨床助教 (80623800)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: アンチエイジング / 肺癌 / klotho / 抗癌剤 / 遺伝子 / Klotho

Research Abstract

We have reported that the klotho gene, which is an anti-aging gene known to be a tumor suppressor, is a prognostic factor for lung cancer patients (Usuda J et al. Lung Cancer. 2011). In this study, we determined whether klotho expression may have a predictive value of the efficacy of anti-cancer agents for cancer treatment. We performed transfection of klotho-plasmid into MCF-7c3 cells, which stably express procaspase-3, and treated the cells with various kinds of anti-cancer agents. A high expression of the klotho protein can markedly increase the apoptotic response of MCF-7c3 cells to docetaxel and paclitaxel. These results suggest that klotho expression may indicate the predictive value of chemotherapy and play an important role in cancer treatment.

Research Products

• [Journal Article] Proposal on incorporating blood vessel invasion into the T classification parts as apractical staging system for stage I non-small cell lung cancer (2013)
  • Author(s): Kudo Y, Saji H, Shimada Y, Matsubayashi J, Nagao T, Kakihana M, Usuda J, Kajiwara N, Ohira T, Ikeda N
  • Journal Title: Lung Cancer Volume: 81 Issue: 2 Pages: 187-193
  • DOI: 10.1016/j.lungcan.2013.04.016
  • Peer Reviewed
• [Presentation] Proposal on incorporating Blood Vessel Invasion into the T classification parts as a practical staging system for stage I Non-small cell Lung Cancer (2013)
  • Author(s): Yujin Kudo, Hisashi Saji, Yoshihisa Shimada, Jun Matsubayashi, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
  • Organizer: 15th World Conference on Lung Cancer
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2013-10-30
• [Presentation] アンチエイジング遺伝子Klotho 発現と抗癌剤感受性との関係 (2013)
  • Author(s): 工藤勇人, 臼田実男, 古本秀行, 今井健太郎, 井上達哉, 大谷圭志, 石角太一郎, 一ノ瀬修二, 垣花昌俊, 梶原直央, 大平達夫, 池田徳彦
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2013-10-04
• [Presentation] Clinical impact of blood vessel invasion in completely resected stage I non-small cell lung cancer (2013)
  • Author(s): Yujin Kudo, Hideyuki Furumoto, Sachio Maehara, Keishi Ohtani, Yoshihisa Shimada, Jun Matsubayashi, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
  • Organizer: 1st International Conference of Federation of Asian Clinical Oncology
  • Place of Presentation: Xiamen, China
  • Year and Date: 2013-09-26
• [Presentation] アンチエイジング遺伝子Klotho 発現にもとづいた術後補助療法の確立をめざして (2013)
  • Author(s): 工藤勇人, 臼田実男, 古本秀行, 石角太一郎, 井上達哉, 池田徳彦
  • Organizer: 第23回日本サイトメトリー学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-06-22
• [Presentation] アンチエイジング遺伝子Klotho 発現にもとづいた術後補助療法の確立をめざして (2013)
  • Author(s): 工藤勇人、臼田実男、古本秀行、石角太一郎、井上達哉、池田徳彦
  • Organizer: 第23回日本サイトメトリー学会学術集会
  • Place of Presentation: 日本医科大学
• [Presentation] アンチエイジング遺伝子Klotho発現と抗癌剤感受性との関係 (2013)
  • Author(s): 工藤勇人、臼田実男、古本秀行、今井健太郎、井上達哉、大谷圭志、石角太一郎、一ノ瀬修二、垣花昌俊、梶原直央、大平達夫、池田徳彦
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Proposal on incorporating Blood Vessel Invasion into the T classification parts as a practical staging system for stage I Non-small cell Lung Cancer (2013)
  • Author(s): Yujin Kudo, Hisashi Saji, Yoshihisa Shimada, Jun Matsubayashi, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
  • Organizer: 15th World Conference on Lung Cancer
  • Place of Presentation: オーストラリア シドニー
• [Presentation] Clinical impact of blood vessel invasion in completely resected stage I non-small cell lung cancer
  • Author(s): Yujin Kudo, Hideyuki Furumoto, Sachio Maehara, Keishi Ohtani, Yoshihisa Shimada, Jun Matsubayashi, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
  • Organizer: 1st International Conference of Federation of Asian Clinical Oncology
  • Place of Presentation: 中国 福建省厦門
• [Presentation] Impact of visceral pleural invasion on the survival of patients with non-small cell lung cancer
  • Author(s): Yujin Kudo, Hisashi Saji, Yoshihisa Shimada, et al.
  • Organizer: 5th Asian Pacific Lung Cancer Congress
  • Place of Presentation: Fukuoka, Japan
• [Remarks]
  • URL: http://team.tokyo-med.ac.jp/kokyukigeka/index.html