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Establishment of patient-derived non-small cell lung cancer xenografts as model for enrichment of cancer stem cell, and identification of lung cancer stem cell.

Research Project

Project/Area Number 24791480
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Thoracic surgery
Research Institution地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所)

Principal Investigator

NAKAGAWA Takayuki  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 研究員 (10626261)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords肺癌 / 癌幹細胞
Research Abstract

In order to develop the new therapeutic strategy for non-small cell lung cancer (NSCLC), I tried to establish patient-derived NSCLC xenografts on the NOG mice and explore the molecules involved in the characteristics of cancer stem cell. We established 15 passagable xenograft lines. A comparison of the histology of original sample with xenografted tumors revealed the similar histologic architecture of the primary and xenograft tumor. As cancer stem cell related molecule, I focused on large non-coding RNA HOTAIR. As expected, the expression of HOTAIR was found especially in aggressive NSCLC.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer2014

    • Author(s)
      Nakagawa T, Endo H, Yokoyama M, Abe J, Tamai K, Tanaka N, Sato I, Takahashi S, Kondo T, Satoh K.
    • Journal Title

      Biochem Biophy Res Commun

      Volume: 436 Issue: 2 Pages: 319-324

    • DOI

      10.1016/j.bbrc.2013.05.101

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer2013

    • Author(s)
      Nakagawa T, Endo H, Yokoyama M, Abe J, Tamai K, Tanaka N, Sato I, Takahashi S, Kondo T, Satoh K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 436 Pages: 319-24

    • Related Report
      2013 Final Research Report
  • [Journal Article] Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer2013

    • Author(s)
      Endo H, Shiroki T, Nakagawa T, Yokoyama M, Tamai K, Yamanami H, Fujiya T, Sato I, Yamaguchi K, Tanaka N, Iijima K, Shimosegawa T, Sugamura K, Satoh K
    • Journal Title

      PLoS ONE

      Volume: 8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer.2013

    • Author(s)
      Endo H, Shiroki T, Nakagawa T, Yokoyama M, Tamai K, Yamanami H, Fujiya T, Sato I, Yamaguchi K, Tanaka N, Iijima K, Shimosegawa T, Sugamura K, Satoh K.
    • Journal Title

      PlosONE

      Volume: 8 Issue: 10 Pages: e77070-e77070

    • DOI

      10.1371/journal.pone.0077070

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 非小細胞肺癌におけるHOTAIRの発現と転移2012

    • Author(s)
      中川隆行, 田中伸幸, 菅村和夫, 佐藤郁郎, 佐藤賢一
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report 2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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