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New Drug Delivery using CED for Spinal cord Astrocytoma

Research Project

Project/Area Number 24791483
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionTohoku University

Principal Investigator

ENDO Toshiki  東北大学, 大学病院, 助教 (00535370)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords脊髄腫瘍 / 薬剤送達 / 抗がん剤
Research Abstract

This research was conducted to develop new treatments for spinal cord malignant glioma. First, to observe the dynamics of delivered drugs in the spinal cord, we injected fluorescent dye in normal rat spinal cord. Having confirmed that the drugs were delivered in the spinal cord without causing motor deficits in the lower extremities and drugs were distributed 3.5 times in larger volumes when compared to the true amount of the drug, we assured it safe and effective strategy. Next, we validated toxicity of antineoplastic agents ACNU to the spinal cord parenchyma. As result, ACNU 1.0 mg/mL was useful as well as tolerable maximum concentration for spinal cord. We then performed ACNU drug delivery treatments to the spinal cord glioma model. Spinal cord tumor suppression and preservation of lower limb motor function were confirmed in 4 out of 16 animals in experiments.
Direct spinal cord injection of ACNU can be a new treatment for spinal cord malignant glioma.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (17 results)

  • [Journal Article] Cognard type V intracranial dural arteriovenous shunt: case reports and literature review with special consideration of the pattern of spinal venous drainage.2014

    • Author(s)
      Haryu S, Endo T, Sato K, Inoue T, Takahashi A, Tominaga T
    • Journal Title

      Neurosurgery

      Volume: 74 Issue: 1 Pages: 135-142

    • DOI

      10.1227/neu.0000000000000069

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical Treatment of Spinal Extradural Arteriovenous Fistula with Parenchymal Drainage: Report on 5 Cases.2013

    • Author(s)
      Niizuma K, Endo T, Sato K, Takada S, Sugawara T, Mikawa S, Tominaga T.
    • Journal Title

      Neurosurgery

      Volume: 73 Pages: onsE287-onsE294

    • DOI

      10.1227/neu.0000000000000189

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of microscope-integrated near-infrared indocyanine green videoangiography in the surgical treatment of intramedullary cavernous malformations: report of 8 cases.2013

    • Author(s)
      Endo T, Aizawa-Kohama M, Nagamatsu K, Murakami K, Takahashi A, Tominaga T.
    • Journal Title

      Journal of Neurosurgery Spine

      Volume: 18 Issue: 5 Pages: 443-449

    • DOI

      10.3171/2013.1.spine12482

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent dural and perimedullary arteriovenous fistulas at the craniocervical junction : case series with special reference to angioarchitecture2013

    • Author(s)
      Sato K, Endo T, Niizuma K, Fujimura M, Inoue T, Shimizu H, Tominaga T
    • Journal Title

      J Neurosurg

      Volume: 118(2) Issue: 2 Pages: 451-9

    • DOI

      10.3171/2012.10.jns121028

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 5-aminolevulinic acid fluorescence-guided resection of intramedullary ependymoma: report of 9 cases.2013

    • Author(s)
      Inoue T, Endo T, Nagamatsu K, Watanabe M, Tominaga T.
    • Journal Title

      Neurosurgery

      Volume: 72 Pages: 159-168

    • DOI

      10.1227/neu.0b013e31827bc7a3

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection2013

    • Author(s)
      Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera JJ, Kawashima R, Tominaga T, Dezawa M
    • Journal Title

      Cell Transplant

      Volume: 22(9) Issue: 9 Pages: 1613-25

    • DOI

      10.3727/096368912x658791

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent dural and perimedullary arteriovenous fistulas at the craniocervical junction: case series with special reference to angioarchitecture.2013

    • Author(s)
      Sato K, Endo T, Niizuma K, Fujimura M, Inoue T, Shimizu H, Tominaga T.
    • Journal Title

      Journal of Neurosurgery

      Volume: 118 Pages: 451-459

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Axial loading during magnetic resonance imaging in patients with lumbar spinal canal stenosis : does it reproduce the positional change of the dural sac detected by upright myelography?2012

    • Author(s)
      Kanno H, Endo T, Ozawa H, Koizumi Y, Morozumi N, Itoi E, Ishii Y
    • Journal Title

      Spine (Phila Pa 1976)

      Volume: 15;37(16) Issue: 16 Pages: E985-E992

    • DOI

      10.1097/brs.0b013e31821038f2

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 頚髄症にて発症した頭蓋内硬膜動静脈瘻 : 早期診断につながる臨床学的特徴2013

    • Author(s)
      遠藤俊毅
    • Organizer
      第45回 脊髄障害医学会
    • Place of Presentation
      福岡
    • Year and Date
      2013-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄腹側Perimedullary Arteriovenous Shunts : 内視鏡併用手術の有用性2013

    • Author(s)
      遠藤俊毅
    • Organizer
      第20回日本神経内視鏡学会
    • Place of Presentation
      山梨
    • Year and Date
      2013-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Cervical Perimedullary Arteriovenous Shunts : 連続22 症例におけるシャント部位と血管構築に基づいた治療ストラテジー2013

    • Author(s)
      遠藤俊毅
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Peculiar Characteristics of Arteriovenous malformations at the Craniocervical Junction : Concurrent dural and perimedullary arteriovenous fistulas at the craniocervical junction2013

    • Author(s)
      Toshiki Endo
    • Organizer
      7th annual meeting of Asia-Pacific Cervical Spine Society 2013
    • Place of Presentation
      札幌
    • Year and Date
      2013-08-22
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット脳/脊髄fMRI : 脊髄損傷後の脳の変化と回復に果たす脳の役割とは2013

    • Author(s)
      遠藤俊毅
    • Organizer
      第28回日本脊髄外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 5ALA Fluorescence guided resection of intramedullary Ependymoma2013

    • Author(s)
      Toshiki Endo
    • Organizer
      81st AANS Annual Scientific Meeting
    • Place of Presentation
      New Orleans アメリカ
    • Year and Date
      2013-04-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄局所薬剤送達にて治療した脊髄神経膠腫の一例2013

    • Author(s)
      遠藤俊毅
    • Organizer
      第49回東北地方会
    • Place of Presentation
      新潟
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 頚髄症にて発症した頭蓋内硬膜動静脈瘻:早期診断につながる臨床学的特徴2013

    • Author(s)
      遠藤俊毅
    • Organizer
      第45回 脊髄障害医学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脊髄腹側Perimedullary Arteriovenous Shunts: 内視鏡併用手術の有用性2013

    • Author(s)
      遠藤俊毅
    • Organizer
      第20回日本神経内視鏡学会
    • Place of Presentation
      山梨
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cervical Perimedullary Arteriovenous Shunts: 連続22症例におけるシャント部位と血管構築に基づいた治療ストラテジー2013

    • Author(s)
      遠藤俊毅
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Peculiar Characteristics of Arteriovenous malformations at the Craniocervical Junction: Concurrent dural and perimedullary arteriovenous fistulas at the craniocervical junction.2013

    • Author(s)
      Toshiki Endo
    • Organizer
      7th annual meeting of Asia-Pacific Cervical Spine Society
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット脳/脊髄fMRI:脊髄損傷後の脳の変化と回復に果たす脳の役割とは2013

    • Author(s)
      遠藤俊毅
    • Organizer
      第28回日本脊髄外科学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 5-ALA / インドシアニングリーンを駆使した脊髄腫瘍摘出術2013

    • Author(s)
      遠藤俊毅
    • Organizer
      第28回日本脊髄外科学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 5ALA Fluorescence guided resection of intramedullary Ependymoma2013

    • Author(s)
      Toshiki Endo
    • Organizer
      81st AANS Annual Scientific Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 5ALA を用いた脊髄上衣腫手術;10例報告2012

    • Author(s)
      遠藤俊毅
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 定位放射線治療を行った胸髄動静脈奇形症例2012

    • Author(s)
      遠藤俊毅
    • Organizer
      第48回東北地方会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄神経膠腫の頭蓋内播種 : 4 症例報告2012

    • Author(s)
      遠藤俊毅
    • Organizer
      第27回日本脊髄外科学会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-22
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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