New Drug Delivery using CED for Spinal cord Astrocytoma
| Project/Area Number |
24791483
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
ENDO Toshiki 東北大学, 大学病院, 助教 (00535370)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脊髄腫瘍 / 薬剤送達 / 抗がん剤 |
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| Research Abstract |
This research was conducted to develop new treatments for spinal cord malignant glioma. First, to observe the dynamics of delivered drugs in the spinal cord, we injected fluorescent dye in normal rat spinal cord. Having confirmed that the drugs were delivered in the spinal cord without causing motor deficits in the lower extremities and drugs were distributed 3.5 times in larger volumes when compared to the true amount of the drug, we assured it safe and effective strategy. Next, we validated toxicity of antineoplastic agents ACNU to the spinal cord parenchyma. As result, ACNU 1.0 mg/mL was useful as well as tolerable maximum concentration for spinal cord. We then performed ACNU drug delivery treatments to the spinal cord glioma model. Spinal cord tumor suppression and preservation of lower limb motor function were confirmed in 4 out of 16 animals in experiments.
Direct spinal cord injection of ACNU can be a new treatment for spinal cord malignant glioma.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection2013
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera JJ, Kawashima R, Tominaga T, Dezawa M
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Journal Title
Cell Transplant
Volume: 22(9)
Issue: 9
Pages: 1613-25
DOI
Related Report
Peer Reviewed
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