Research for epigenetic markers and targeted therapy for malignant glioma
Project/Area Number |
24791486
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cerebral neurosurgery
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Research Institution | The University of Tokyo |
Principal Investigator |
SAITO Kuniaki 東京大学, 医学部附属病院, 助教 (50446564)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 神経膠腫 / エピジェネティクス / メチル化 / CIMP / 悪性転化 / 個別化療法 / 網羅的解析 / Isocitrate dehydrogenase |
Research Abstract |
Genome-wide methylation analysis of over 100 gliomas including matched-pairs of initial low-grade gliomas and recurrent tumors identified CpG island methylator phenotype (CIMP). Remarkably, approximately 50% of secondary glioblastomas that had progressed from low-grade tumors with the CIMP status exhibited a characteristic partial demethylation of genomic DNA during malignant progression. Demethylation might be one mechanism of malignant progression. Specifically, we identified demethylation and upregulation of IGFBP2 after malignant progression of low grade gliomas. IGFBP2 methylation was prognostic factor of malignantly progressed gliomas, and could be used as a methylation marker and a therapeutic target.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] H3F3A K27M mutations in thalamic gliomas from young adult patients2014
Author(s)
Aihara K, Mukasa A, Gotoh K, Saito K, Nagae G, Tsuji S, Tatsuno K, Yamamoto S, Takayanagi S, Narita Y, Shibui S, Aburatani H, Saito N
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Journal Title
Neuro Oncol
Volume: 16
Issue: 1
Pages: 140-146
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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