The role of cysteinyl leukotrienes in thrombosis

• Project/Area Number: 24791489
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: The University of Tokyo
• Principal Investigator: ITO Akihiro 東京大学, 医学部附属病院, 助教 (10609598)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: システイニルロイコトリエン / 血小板凝集 / 脳血管障害 / 血栓症 / ロイコトリエン

Outline of Final Research Achievements

Cysteinyl leukotrienes are a family of lipid mediators synthesized from arachidonic acid through the 5-lipoxygenase pathway. We demonstrated that leukotriene C4 (LTC4) were potent to inducer of murine platelet aggregation and clarify their potential roles in the pathogenesis of cardiovascular/cerebrovascular disease using the in vivo thrombosis model with knockout mouse of the receptor of CysLTs.