| Project/Area Number |
24791496
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Nagoya University (2013-2014)
Kyoto University (2012) |
|---|
Principal Investigator |
ARAKI YOSHIO 名古屋大学, 医学部附属病院, 病院助教 (80467290)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | もやもや病 / 脳脊髄液 / タンパク解析 / 遺伝子解析 / ペプチド / ELISA / 網羅的遺伝子解析 / マイクロアレイ / もやもや病特異的タンパク / バイオマーカー |
|---|
| Outline of Final Research Achievements |
In our biomarker research study for MMD, the 4473Da peptide is supposed to be a reliable biomarker of MMD. The higher 4473Da peptide peaks in younger MMD patients are proved to be highly associated with postoperative angiogenesis (Maruwaka M, J Stroke and Cerebrovasc Dis.2015). This research was unfortunately unsuccessful to establish a quantitative assessment system of biomarker using ELISA. On the other hand, genetic analysis of vessel samples showed mutation in RNF 213 related pathway.
|
