Identification of molecular targets for malignant glioma stem cells and stem cell niche.

• Project/Area Number: 24791499
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka University
• Principal Investigator: KIJIMA Noriyuki 大阪大学, 医学(系)研究科(研究院), 特任研究員 (80534627)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: グリオーマ幹細胞 / 幹細胞niche / ALCAM / ＡＬＣＡＭ

Outline of Final Research Achievements

In this research project, we examined the functional roles of CD166/activated leukocyte cell adhesion molecule (ALCAM) in glioblastoma. We found that ALCAM is involved in glioblastoma angiogenesis through VEGF independent mechanism.
Our results suggest that ALCAM could be a new anti-angiogeneic agent in glioblastoma.

Research Products

• [Journal Article] Wilms' tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis. (2014)
  • Author(s): Kijima N, Hosen N, Kagawa N, Hashimoto N, Kinoshita M, Oji Y, Sugiyama H, Yoshimine T.
  • Journal Title: Anticancer Research Volume: 34 Pages: 61-67
  • Peer Reviewed
• [Journal Article] CD166/Activated leukocyte cell adhesion molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion (2011)
  • Author(s): Noriyuki Kijima
  • Journal Title: Neuro-Oncology Volume: (in press) Issue: 10 Pages: 1254-1264
  • DOI: 10.1093/neuonc/nor202
  • Peer Reviewed
• [Presentation] 悪性神経膠腫におけるCD166/Activated leukocyte cell adhesion moleculeの発現と腫瘍血管新生における機能的役割 (2012)
  • Author(s): 木嶋教行
  • Organizer: 第30回日本脳腫瘍学会
  • Place of Presentation: 広島
• [Presentation] CD166/ALCAM is expressed in glioblastoma endothelial cells and is involved in the regulation of glioblastoma angiogenesis through the regulation of interleukin 8
  • Author(s): Noriyuki Kijima , Naoki Hosen, Naoki Kagawa, Naoya Hashimoto, Yasuyoshi Chiba, Manabu Kinoshita, Haruo Sugiyama, Toshiki Yoshimine
  • Organizer: SNO 4th Quadrennial Meeting of the World Federation of Neuro-Oncology
  • Place of Presentation: California Marriott Marquis Hotel(San Francisco, USA)