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Epigenetic subclassification and molecular biological research on malignant subgroups of meningiomas

Research Project

Project/Area Number 24791514
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionFukushima Medical University

Principal Investigator

KISHIDA YUGO  福島県立医科大学, 医学部, 講師 (00467292)

Co-Investigator(Kenkyū-buntansha) WADA Ikuo  福島県立医科大学, 細胞科学, 教授 (40182969)
INOUE Naokazu  福島県立医科大学, 細胞科学, 准教授 (50379096)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords髄膜腫 / DNAメチル化 / 悪性転化 / 蛋白発現 / メチル化 / 放射線感受性 / 放射線抵抗性 / HOX遺伝子
Outline of Final Research Achievements

Some populations of meningiomas show malignant clinical behavior in despite of benign histological diagnosis.In this study, novel diagnostic criteria other than histological classification to determine malignant subgroup of meningiomas is presented. A subgroup of meningiomas is characterized by aberrant hypermethylation of the subset of genes in the early stage of tumorigenesis, and our findings highlight the possibility of speculating potential malignancy of meningiomas by assessing methylation status. On the other hand, molecular biological studies about function of hypermethylated genes didn’t show reproducible results. Fukushima medical university brain tumor tissue bank established for basic research has collected over 250 cases of intracranial tumors.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Epigenetic subclassification of meningiomas based on genome-wide DNA methylation analyses2012

    • Author(s)
      Kishida Y, Kondo Y, 12名
    • Journal Title

      Carcinogenesis

      Volume: 33 Issue: 2 Pages: 436-441

    • DOI

      10.1093/carcin/bgr260

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Epigenetic subclassification of meningiomas based on genome-wide DNA methylation analyses2013

    • Author(s)
      岸田 悠吾
    • Organizer
      景山直樹賞受賞講演
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Research-status Report
  • [Presentation] DNAメチル化からみた髄膜腫の再分類と、その臨床応用2012

    • Author(s)
      岸田 悠吾
    • Organizer
      神経皮膚症候群調査研究班班会議
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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