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Molecular risk factors of skull base chordomas

Research Project

Project/Area Number 24791519
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionKeio University

Principal Investigator

KITAMURA Yohei  慶應義塾大学, 医学部, 助教 (30445382)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords頭蓋底 / 脊索腫 / brachyury / T遺伝子 / 2番染色体 / chordoma / CGH / FISH
Research Abstract

Chordoma is an invasive tumor that develops from notochordal remnants and frequently occurs in skull base. T gene and its product (brachyury) have been recently suggested to play an important role in chordoma progression. We analyzed skull base chordomas for chromosomal copy number aberrations by comparative genomic hybridization, brachyury expression by immunohistochemistry, and T gene copy number by fluorescence in situ hybridization. Statistical analyses demonstrated that losses on chromosome 1p and gains on 1q, 2p, expression of brachyury, and gain of T gene were significantly associated with shorter progression free survival. Our results suggest that brachyury-negative chordomas are biologically distinct from brachyury-positive chordomas, and T/brachyury might be one of the best molecular therapeutic targets of chordoma.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results)

  • [Journal Article] Supratentorial neurenteric cyst with spontaneous repetitive intracystic hemorrhage mimicking brain abscess: a case report2014

    • Author(s)
      Kitamura Y, Sasaki H, Hashiguchi A, Momoshima S, Shidoh S, Yoshida K
    • Journal Title

      Neurosurg Rev

      Volume: 37(1) Issue: 1 Pages: 153-159

    • DOI

      10.1007/s10143-013-0476-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis.2013

    • Author(s)
      Kitamura Y, Sasaki H, Kimura T, Miwa T, Takahashi S, Kawase T, Yoshida K
    • Journal Title

      Journal of Neuropathology and Experimental Neurology

      Volume: 72(9) Issue: 9 Pages: 814-823

    • DOI

      10.1097/nen.0b013e3182a065d0

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optic nerve seeding of atypical meningiomas presenting with subacute visual loss: two case reports with genetic characterization2013

    • Author(s)
      Kitamura Y, Akiyama T, Sasaki H, Hayashi Y, Yoshida K
    • Journal Title

      J Neurosurgery

      Volume: 119(2) Issue: 2 Pages: 494-498

    • DOI

      10.3171/2013.1.jns121533

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optic nerve seeding of atypical meningiomas presenting with subacute visual loss: two case reports with genetic characterization2013

    • Author(s)
      Kitamura Y, Akiyama T, Sasaki H, Hayashi Y, Yoshida K
    • Journal Title

      J Neurosurg

      Volume: Epub ahead of print

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Infratentorial low-grade oligoastrocytoma with aggressive clinical behavior in an adult: a case report with genetic characterization2013

    • Author(s)
      Sano K, Toda M, Sasaki H, Kitamura Y, Mikami S, Hirato J, Inoue S, Kawase T, Yoshida K
    • Journal Title

      Brain Tumor Pathol

      Volume: 30(2) Issue: 2 Pages: 99-103

    • DOI

      10.1007/s10014-012-0111-3

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular and genetic profiles of radiographically defined de novo meningiomas2012

    • Author(s)
      Kitamura Y, Sasaki H, Yoshida K
    • Journal Title

      Journal of Neuro-Oncology

      Volume: (in press) Issue: 1 Pages: 37-44

    • DOI

      10.1007/s11060-012-0797-4

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 頭蓋底脊索腫の分子生物学的特徴と予後因子の検討2013

    • Author(s)
      北村洋平, 佐々木光, 木村徳宏, 三輪点, 高橋里史, 河瀬斌, 吉田一成
    • Organizer
      日本頭蓋底外科学会
    • Place of Presentation
      名古屋東急ホテル(名古屋)
    • Year and Date
      2013-06-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭蓋底脊索腫の分子生物学的特徴と予後因子の検討2013

    • Author(s)
      北村 洋平, 佐々木 光, 木村 徳宏, 三輪 点, 高橋 里史, 河瀬 斌, 吉田 一成
    • Organizer
      第25回日本頭蓋底外科学会
    • Place of Presentation
      名古屋東急ホテル(名古屋)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 頭蓋底脊索腫の分子生物学的解析と予後因子の検討2012

    • Author(s)
      北村洋平, 佐々木光, 木村徳宏, 三輪点, 高橋里史, 河瀬斌, 吉田一成
    • Organizer
      日本脳神経外科学会総会
    • Place of Presentation
      グランキューブ大阪(大阪)
    • Year and Date
      2012-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭蓋底脊索腫の分子生物学的解析と予後因子の検討

    • Author(s)
      北村洋平
    • Organizer
      日本脳神経外科学会第71回学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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