Research Project
Grant-in-Aid for Young Scientists (B)
Several studies have aimed to detect biomarkers in glioma using noninvasive imaging techniques. This study examines the correlation between 11C-methionine uptake and MGMT promoter methylation in grade Ⅱ and grade Ⅲ nonenhancing gliomas.Data was collected from 20 patients with grade Ⅱ and Ⅲ nonenhancing gliomas who underwent both MRI and 11C-methionine PET as part of their pre-surgical examination. We examined MGMT promoter methylation by quantitative methylation-specific PCR.The mean MGMT promoter methylation for tumors with T/N ratios ≧1.6 was 28.0 ± 26.3, and that for tumors with T/N ratios <1.6 was 0.68 ± 0.89. The MGMT promoter methylation for tumors with T/N ratios ≧1.6 was significantly higher than that for tumors with T/N ratios <1.6 (P < 0.05).A higher uptake in 11C-methionine PET may reflect increased MGMT promoter methylation. 11C-methionine PET could be a useful tool to detect MGMT promoter methylation in nonenhancing glioma.
All 2015 2014 2013 2012
All Journal Article (18 results) (of which Peer Reviewed: 17 results, Acknowledgement Compliant: 2 results, Open Access: 1 results) Presentation (16 results) (of which Invited: 1 results) Book (1 results)
BMC Neurology
Volume: 15 Issue: 1 Pages: 25-25
10.1186/s12883-015-0286-4
Oncol Lett.
Volume: 9(4) Pages: 1885-1888
Neuro Oncol
Volume: 16 Issue: 5 Pages: 728-734
10.1093/neuonc/not319
Clin Neurol Neurosurg
Volume: 125 Pages: 212-216
10.1016/j.clineuro.2014.08.004
脳神経外科ジャーナル
Volume: vol23 no.1 Pages: 46-58
130003397685
Volume: 23 Pages: 46-58
Childs Nerv Syst
Volume: 29 Issue: 2 Pages: 341-345
10.1007/s00381-012-1948-9
Molecular and Clinical Oncology
Volume: 1 Pages: 995-1001
脳神経外科速報
Volume: 23 Pages: 316-323
Journal of Neurosurgery
Volume: (in press) Issue: 4 Pages: 835-842
10.3171/2011.12.jns111255
Brain Tumor Pathol.
Volume: 29 Issue: 4 Pages: 192-200
10.1007/s10014-012-0084-2
Neuropathology
Volume: 32 Issue: 6 Pages: 604-610
10.1111/j.1440-1789.2012.01303.x
Clin Neurol Neurosurg.
Volume: 114 Issue: 9 Pages: 1217-1221
10.1016/j.clineuro.2012.02.053
Volume: 29 Issue: 4 Pages: 183-191
10.1007/s10014-012-0113-1
Asia Pac J Clin Oncol.
Volume: 8 Issue: 4
10.1111/j.1743-7563.2012.01561.x
Pediatr Hematol Oncol.
Volume: 29 Pages: 647-651
J Nucl Med
Volume: 53(11) Issue: 11 Pages: 1701-1708
10.2967/jnumed.112.104992
Intern Med.
Volume: 51 Pages: 2967-2971
130002062100