11C-methinine uptake correlates with MGMT promoter methylation in nonenhancing gliomas
| Project/Area Number |
24791520
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | National Hospital Organization Osaka National Hospital Institute for Clinical Reserch (2013-2014)
Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2012) |
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Principal Investigator |
OKITA Yoshiko 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 (10533797)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | glioma / MET-PET / MGMT / IDH1 |
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| Outline of Final Research Achievements |
Several studies have aimed to detect biomarkers in glioma using noninvasive imaging techniques. This study examines the correlation between 11C-methionine uptake and MGMT promoter methylation in grade Ⅱ and grade Ⅲ nonenhancing gliomas.Data was collected from 20 patients with grade Ⅱ and Ⅲ nonenhancing gliomas who underwent both MRI and 11C-methionine PET as part of their pre-surgical examination. We examined MGMT promoter methylation by quantitative methylation-specific PCR.The mean MGMT promoter methylation for tumors with T/N ratios ≧1.6 was 28.0 ± 26.3, and that for tumors with T/N ratios <1.6 was 0.68 ± 0.89. The MGMT promoter methylation for tumors with T/N ratios ≧1.6 was significantly higher than that for tumors with T/N ratios <1.6 (P < 0.05).A higher uptake in 11C-methionine PET may reflect increased MGMT promoter methylation. 11C-methionine PET could be a useful tool to detect MGMT promoter methylation in nonenhancing glioma.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] 2.Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis.2014
Author(s)
Kinoshita M1, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T
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Journal Title
Neuro Oncol
Volume: 16
Issue: 5
Pages: 728-734
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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