11C-methinine uptake correlates with MGMT promoter methylation in nonenhancing gliomas

• Project/Area Number: 24791520
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: National Hospital Organization Osaka National Hospital Institute for Clinical Reserch (2013-2014); Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2012)
• Principal Investigator: OKITA Yoshiko 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 (10533797)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: glioma / MET-PET / MGMT / IDH1

Outline of Final Research Achievements

Several studies have aimed to detect biomarkers in glioma using noninvasive imaging techniques. This study examines the correlation between 11C-methionine uptake and MGMT promoter methylation in grade Ⅱ and grade Ⅲ nonenhancing gliomas.Data was collected from 20 patients with grade Ⅱ and Ⅲ nonenhancing gliomas who underwent both MRI and 11C-methionine PET as part of their pre-surgical examination. We examined MGMT promoter methylation by quantitative methylation-specific PCR.The mean MGMT promoter methylation for tumors with T/N ratios ≧1.6 was 28.0 ± 26.3, and that for tumors with T/N ratios <1.6 was 0.68 ± 0.89. The MGMT promoter methylation for tumors with T/N ratios ≧1.6 was significantly higher than that for tumors with T/N ratios <1.6 (P < 0.05).A higher uptake in 11C-methionine PET may reflect increased MGMT promoter methylation. 11C-methionine PET could be a useful tool to detect MGMT promoter methylation in nonenhancing glioma.

Research Products

• [Journal Article] Ipsilateral hemiparesis caused by putaminal hemorrhage in a patient with horizontal gaze palsy with progressive scoliosis: a case report. (2015)
  • Author(s): Yamada S, Okita Y, Shofuda T, Yoshioka E, Nonaka M, Mori K, Nakajima S, Kanemura Y.
  • Journal Title: BMC Neurology Volume: 15 Issue: 1 Pages: 25-25
  • DOI: 10.1186/s12883-015-0286-4
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report. (2015)
  • Author(s): Okita Y
  • Journal Title: Oncol Lett. Volume: 9(4) Pages: 1885-1888
  • Peer Reviewed
• [Journal Article] 2.Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis. (2014)
  • Author(s): Kinoshita M1, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T
  • Journal Title: Neuro Oncol Volume: 16 Issue: 5 Pages: 728-734
  • DOI: 10.1093/neuonc/not319
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] (11)C-methinine uptake correlates with MGMT promoter methylation in nonenhancing gliomas. (2014)
  • Author(s): Okita Y, Nonaka M, Shofuda T, Kanematsu D, Yoshioka E, Kodama Y, Mano M, Nakajima S, Kanemura Y.
  • Journal Title: Clin Neurol Neurosurg Volume: 125 Pages: 212-216
  • DOI: 10.1016/j.clineuro.2014.08.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 神経膠腫患者の認知機能・QOL研究の現状と課題 (2014)
  • Author(s): 沖田典子
  • Journal Title: 脳神経外科ジャーナル Volume: vol23 no.1 Pages: 46-58
  • NAID: 130003397685
  • Peer Reviewed
• [Journal Article] 神経膠腫患者の認知機能・QOL研究の現状と課題. (2014)
  • Author(s): 沖田典子
  • Journal Title: 脳神経外科ジャーナル Volume: 23 Pages: 46-58
  • NAID: 130003397685
• [Journal Article] Management of glioblastoma in an nf1 patient with moyamoya syndrome : A case report (2013)
  • Author(s): Arita H, Narita Y, Ohno M, Miyakita Y, Okita Y, Ide T, Shibui S
  • Journal Title: Childs Nerv Syst Volume: 29 Issue: 2 Pages: 341-345
  • DOI: 10.1007/s00381-012-1948-9
  • Peer Reviewed
• [Journal Article] Extended trastuzumab therapy improves the survival of HER2-positive breast cancer patients after surgery and radiotherapy for brain metastases. (2013)
  • Author(s): Okita Y
  • Journal Title: Molecular and Clinical Oncology Volume: 1 Pages: 995-1001
  • Peer Reviewed
• [Journal Article] テモゾロミドと日和見感染 －ニューモシスチス肺炎とサイトメガロウィルス・ B 型肝炎ウィルスの活性化について－ (2013)
  • Author(s): 大野誠
  • Journal Title: 脳神経外科速報 Volume: 23 Pages: 316-323
  • Peer Reviewed
• [Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma (2012)
  • Author(s): Yasuyoshi Chiba
  • Journal Title: Journal of Neurosurgery Volume: (in press) Issue: 4 Pages: 835-842
  • DOI: 10.3171/2011.12.jns111255
  • Peer Reviewed
• [Journal Article] Pathological findings and prognostic factors in recurrent glioblastomas. (2012)
  • Author(s): Okita Y
  • Journal Title: Brain Tumor Pathol. Volume: 29 Issue: 4 Pages: 192-200
  • DOI: 10.1007/s10014-012-0084-2
  • Peer Reviewed
• [Journal Article] A case of unclassified high-grade glioma with polar spongioblastoma pattern. (2012)
  • Author(s): Fukushima S
  • Journal Title: Neuropathology Volume: 32 Issue: 6 Pages: 604-610
  • DOI: 10.1111/j.1440-1789.2012.01303.x
  • Peer Reviewed
• [Journal Article] Long-term follow-up of vanishing tumors in the brain: how should a lesion mimicking primary CNS lymphoma be managed? (2012)
  • Author(s): Okita Y
  • Journal Title: Clin Neurol Neurosurg. Volume: 114 Issue: 9 Pages: 1217-1221
  • DOI: 10.1016/j.clineuro.2012.02.053
  • Peer Reviewed
• [Journal Article] Histopathological malignant progression of grade II and III gliomas correlated with IDH1/2 mutation status. (2012)
  • Author(s): Ohno M
  • Journal Title: Brain Tumor Pathol. Volume: 29 Issue: 4 Pages: 183-191
  • DOI: 10.1007/s10014-012-0113-1
  • Peer Reviewed
• [Journal Article] Development of secondary skull sarcoma after treatment for childhood acute myeloid leukemia. (2012)
  • Author(s): Ohno M
  • Journal Title: Asia Pac J Clin Oncol. Volume: 8 Issue: 4
  • DOI: 10.1111/j.1743-7563.2012.01561.x
  • Peer Reviewed
• [Journal Article] The late recurrence of ganglioneuroma 21 years after initial presentation with neuroblastoma. (2012)
  • Author(s): Okita Y
  • Journal Title: Pediatr Hematol Oncol. Volume: 29 Pages: 647-651
  • Peer Reviewed
• [Journal Article] A novel PET index, 18F-FDG-11C-methionine uptake decoupling score, reflects glioma cell infiltration. (2012)
  • Author(s): Kinoshita M
  • Journal Title: J Nucl Med Volume: 53(11) Issue: 11 Pages: 1701-1708
  • DOI: 10.2967/jnumed.112.104992
  • Peer Reviewed
• [Journal Article] Management of cytomegalovirus infection in a patient with malignant glioma treated with temozolomide and steroids. (2012)
  • Author(s): Okita Y
  • Journal Title: Intern Med. Volume: 51 Pages: 2967-2971
  • NAID: 130002062100
  • Peer Reviewed
• [Presentation] 非造影神経膠腫における11C-methionine PETでのMGMTプロモーターメチル化率の予測 (2014)
  • Author(s): 沖田典子
  • Organizer: 第32回日本脳腫瘍学会学術集会
  • Place of Presentation: シェラトン・グランデ・トーキョーベイ・ホテル
  • Year and Date: 2014-12-01
• [Presentation] 非造影神経膠腫における11C-methionine PETでのMGMTプロモーターメチル化率の予測について (2014)
  • Author(s): 沖田典子
  • Organizer: 第73回日本脳神経外科学会総会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2014-10-16
• [Presentation] Low grade gliomaにおけるFLAIR画像での境界不鮮明症例の摘出について (2014)
  • Author(s): 沖田典子
  • Organizer: 第19回日本脳腫瘍の外科学会
  • Place of Presentation: 東京ドームホテル
  • Year and Date: 2014-09-12
• [Presentation] 再発時に癌性髄膜炎を認めた症例でのアバスチンの治療効果について (2014)
  • Author(s): 沖田典子
  • Organizer: 脳腫瘍を考える会
  • Place of Presentation: 帝国ホテル大阪
  • Year and Date: 2014-05-09
• [Presentation] 乳癌脳転移巣のホルモンレセプターの変化に基づく治療戦略について (2013)
  • Author(s): 沖田典子
  • Organizer: 第73回日本脳神経外科学会総会
  • Place of Presentation: パシィフィコ横浜
• [Presentation] 乳癌による転移性脳腫瘍の臨床像と予後の検討 (2013)
  • Author(s): 沖田典子
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 国立京都国際会館・グランドプリンス京都
• [Presentation] AIDS患者における脳深部病変に対する内視鏡下生検術の有用性 (2013)
  • Author(s): 沖田典子
  • Organizer: 第20回日本神経内視鏡学会
  • Place of Presentation: 甲府富士屋ホテル
• [Presentation] GradeIIgliomaの長期生存者でのQOL調査について (2013)
  • Author(s): 沖田典子
  • Organizer: 第31回日本脳腫瘍学会学術集会
  • Place of Presentation: フェニックス・シーガイア・リゾート
• [Presentation] 成人Grade2 gliomaの病理像・IDH変異・1p/19q LOHの予後との相関に ついて (2012)
  • Author(s): 沖田典子
  • Organizer: 第30回日本脳腫瘍病理学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 乳がんによる転移性脳腫瘍の臨床像と予後の検討 (2012)
  • Author(s): 沖田典子
  • Organizer: 一般社団法人日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 肺がん脳転移：外科的切除例での検討 がん脳転移に対する新しい治療指針の確立に向けて (2012)
  • Author(s): 丸野元彦
  • Organizer: 一般社団法人日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Grade2 gliomaのIDH1/2変異と放射線化学療法の有効性について (2012)
  • Author(s): 成田善孝
  • Organizer: 一般社団法人日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪国際会議場
  • Invited
• [Presentation] Grade2、grade3 gliomaの病理像・IDH1変異とMET-PET、FDG-PETとの検討 (2012)
  • Author(s): 沖田典子
  • Organizer: 第30回日本脳腫瘍学会学術集会
  • Place of Presentation: グランドプリンスホテル広島
• [Presentation] 肺がんおよび乳がんの脳転移：臨床像からの解析 (2012)
  • Author(s): 丸野元彦
  • Organizer: 第30回日本脳腫瘍学会学術集会
  • Place of Presentation: グランドプリンスホテル広島
• [Presentation] グリオーマにおける1p19q共欠失とα-internexin発現との関連 (2012)
  • Author(s): 千葉泰良
  • Organizer: 第30回日本脳腫瘍学会学術集会
  • Place of Presentation: グランドプリンスホテル広島
• [Presentation] 悪性神経膠腫に対するテモゾロミド投与によるリンパ球減少とウイルスの再活性化 (2012)
  • Author(s): 宝田秀憲
  • Organizer: 第30回日本脳腫瘍学会学術集会
  • Place of Presentation: グランドプリンスホテル広島
• [Book] 転移性脳腫瘍 診断・治療・管理マニュアル 第6章 がん種別における転移性脳腫瘍の特徴 (2014)
  • Author(s): 沖田典子
  • Publisher: MCメディカ出版