Does microparticles induce innate immunity with stimulation plasmacytoid dendritic cells in rheumatic diseases?
Project/Area Number |
24791522
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Yamagata University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 関節リウマチ / 微小粒子 / 自然免疫 / 樹状細胞 / Toll-like receptor / リウマチ / 形質細胞様樹状細胞 / サイトカイン / toll 様受容体 / 国際情報交換 |
Outline of Final Research Achievements |
Rheumatic diseases are chronic and systemic autoimmune inflammatory diseases. However, the original causes of rheumatic diseases are unknown yet. Microparticles are complex structures composed of a lipid bilayer that contains transmembrane proteins and encloses soluble hydrophilic components derived from the cytosol of the donor cell, including DNA, RNA or nucleus proteins in themselves. Plasmacytoid dendritic cells (pDCs) are an important role as innate inflammatory in rheumatic diseases. The aim of study is to assess the reaction of plasmacytoid DC by stimulating of MPs in rheumatic diseases. Microparticles induced the expression of TLR7 and TLR9 on pDCs. MPs and ABs may play a role in the onset and maintenance of rheumatic disease via TLR pathways.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] 過去10年間の関節リウマチ患者に対するメソトレキセート投与量の経年的変化と重篤な有害事象の発生率2015
Author(s)
高窪祐弥, 結城北斗, 金野昇, 梁秀蘭, 大木弘治, 平山朋幸, 佐々木明子, 長沼靖, 佐々木幹, 大類広, 高木理彰
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Peer Reviewed
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[Journal Article] 過去10年間の関節リウマチ (RA)患者に対する人工関節手術件数の推移2014
Author(s)
高窪祐弥, 佐々木幹, 大木弘治, 平山朋幸, 成田淳, 浅野多聞, 玉木康信, 冨樫栄太, 川路博之, 福島重宣, 石井政次, 高木理彰
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Journal Title
日本人工関節学会誌
Volume: 44
Pages: 741-742
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[Journal Article] 過去10年間の高齢者不安定型骨盤輪損傷症例の検討2014
Author(s)
高窪祐弥, 佐々木幹, 大木弘治, 平山朋幸, 赤羽武, 和根崎禎大, 高木理彰, 玉木康信, 川路博之, 石井政次, 小林真司
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Journal Title
Hip Joint
Volume: 40
Pages: 466-468
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Peer Reviewed
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[Presentation] Are atypical femoral fractures in rheumatic patients increasing?2015
Author(s)
Yuya Takakubo, Syouta Okuda, Yasushi Naganuma, Ryuta Ooishi, Hiroharu Oki, Yasuhobu Tamaki, Akiko Sasaki, Atsushi Narita, Tomoyuki Hirayama, Kan Sasaki, Michiaki Takagi
Organizer
European League Against Rheumatism 2015
Place of Presentation
Fiera Roma, Roma, Italy
Year and Date
2015-06-09 – 2015-06-13
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[Presentation] 高窪祐弥, 大木弘治, 佐々木幹, 玉木康信, 梁秀蘭, 成田淳, 佐々木明子, 長沼靖, 高木理彰2014
Author(s)
高窪祐弥, 大木弘治, 佐々木幹, 玉木康信, 梁秀蘭, 成田淳, 佐々木明子, 長沼靖, 高木理彰
Organizer
第29回日本整形基礎学術集会
Place of Presentation
城山観光ホテル,鹿児島
Year and Date
2014-10-09 – 2014-10-10
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[Presentation] THE CONCENTRATION OF SERUM INTERLEUKIN-6 BEFORE BIOLOGIC TREATMENT ARE RELATED TO CLINICAL RESPONSE IN THE PATIENTS OF RHEUMATOID ARTHRITIS2014
Author(s)
Yuya Takakubo, Hiroharu Ohki, Suran Yang, Akiko Sasaki, Kan Sasaki, Tomoyuki Hirayama, Yasunobu Tamaki, Yasushi Naganuma, Hiroshi Orui, Michiaki Takagi
Organizer
European League Against Rheumatism 2014
Place of Presentation
Le Palais des Congres de Paris, Paris in France
Year and Date
2014-06-11 – 2014-06-14
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[Presentation] IS PODOPLANIN A NEW CANDIDATE OF INFLAMMATORY MARKERS FOR RHEUMATOID ARTHRITIS?2014
Author(s)
Yuya Takakubo, Hiroharu Ohki, Suran Yang, Akiko Sasaki, Kan Sasaki, Tomoyuki Hirayama, Yasunobu Tamaki, Yasushi Naganuma, Yukinari Kato, Michiaki Takagi
Organizer
European League Against Rheumatism 2014
Place of Presentation
Le Palais des Congres de Paris, Paris in France
Year and Date
2014-06-11 – 2014-06-14
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[Presentation] 高齢者不安定型骨盤輪損傷症例の治療経過の検討2014
Author(s)
高窪祐弥, 佐々木幹, 成田淳, 長谷川浩士, 成田亜矢, 金内ゆみ子, 小林真司, 高木理彰
Organizer
第51回日本リハビリテーション医学会学術集会
Place of Presentation
名古屋国際会議場,名古屋
Year and Date
2014-06-05 – 2014-06-07
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[Presentation] 超高齢社会にむけたリウマチ治療の未来‐東日本(山形県)の取り組み-2014
Author(s)
高窪祐弥, 佐々木幹,玉木康信, 梁秀蘭, 大木弘治, 平山朋幸, 佐々木明子, 長沼靖, 大類広, 高木理彰
Organizer
第87回日本整形外科学会
Place of Presentation
神戸国際会議場, 神戸
Year and Date
2014-05-21 – 2014-05-25
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Invited
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[Presentation] RA滑膜組織における生物学的製剤の自然免疫系への影響2014
Author(s)
高窪祐弥, 玉木康信, 梁秀蘭, 大木弘治, 平山朋幸, 佐々木明子, 長沼靖, 佐々木幹, 大類広, 高木理彰
Organizer
第57回日本リウマチ学会総会・学術集会
Place of Presentation
グランドプリンスホテル,東京
Year and Date
2014-04-24 – 2014-04-26
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