Development of porous/dense composite polyurethane scaffold for bone tissue repair
Project/Area Number |
24791526
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
YOSHII Toshitaka 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (50583754)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | ポリウレタン / scaffold / 骨再生 / ポリウレタンscaffold / 生体吸収性 / 整形外科 / 人工材料 |
Outline of Final Research Achievements |
The efficacy of polyurethane (PUR) scaffold has been reported as a scaffold in bone tissue engineering. To improve mechanical strength of PUR scaffold, we have added calcium phosphate (CaP) to resin component before polymerization. The mechanical property of PUR-CaP and in vitro osteoconductivity were evaluated. Favorable mechanical strength was obtained by adding 70 and 79 weight % of CaP. In vitro preosteoblast culture showed good proliferation and osteogenic differentiation of the cells on the PUR/CaP. Furthermore, we made hollow-shaped PUR/HA combined with highly porous PUR. The metical property of this composite PUR was evaluated. In vivo osteoconductivity of the composite PUR was examined in rat bone defect model.
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Report
(4 results)
Research Products
(11 results)