| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The efficacy of polyurethane (PUR) scaffold has been reported as a scaffold in bone tissue engineering. To improve mechanical strength of PUR scaffold, we have added calcium phosphate (CaP) to resin component before polymerization. The mechanical property of PUR-CaP and in vitro osteoconductivity were evaluated. Favorable mechanical strength was obtained by adding 70 and 79 weight % of CaP. In vitro preosteoblast culture showed good proliferation and osteogenic differentiation of the cells on the PUR/CaP. Furthermore, we made hollow-shaped PUR/HA combined with highly porous PUR. The metical property of this composite PUR was evaluated. In vivo osteoconductivity of the composite PUR was examined in rat bone defect model.
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