Treatment strategies for soft tissue sarcomas

• Project/Area Number: 24791527
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SAWAMURA Chigusa 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (20574247)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 軟部腫瘍 / 再発 / 軟部肉腫

Outline of Final Research Achievements

Patients with local recurrence of soft tissue sarcomas have a poor overall survival. We sought risk factors predictive of local recurrence of soft tissue sarcomas and asked whether radiation and chemotherapy influenced local　recurrence. Patients who had local recurrences had high-grade tumors, positive margins and had treated with radiotherapy. 95% of local recurrences were found if patients were followed for 9 years. Follow-up beyond 10 years does not yield a sufficient number of recurrences or metastases to warrant further monitoring.

Research Products

• [Journal Article] How long should we follow patients with soft tissue sarcomas? (2014)
  • Author(s): Sawamura C, Matsumoto S, Shimoji T, Okawa A, Ae K
  • Journal Title: Clin Orthop Relat Res Volume: 472(3) Issue: 3 Pages: 842-8
  • DOI: 10.1007/s11999-013-3076-6
  • Peer Reviewed
• [Journal Article] Lymphadenectomy and histologic subtype affect overall survival of soft tissue sarcoma patients with nodal metastases. (2013)
  • Author(s): Sawamura C
  • Journal Title: Clinical Orthopaedics and Related Research Volume: 2013 Mar;471(3) Issue: 3 Pages: 926-31
  • DOI: 10.1007/s11999-012-2568-0
  • Peer Reviewed
• [Presentation] How long and how frequently should we follow up patients with soft tissue sarcomas? (2012)
  • Author(s): 澤村 千草
  • Organizer: European Musculoskeletal Oncology Society
  • Place of Presentation: イタリア
• [Presentation] Follow Up Strategies for Soft Tissue Sarcomas (2012)
  • Author(s): 澤村 千草
  • Organizer: Asia Pacific Musculoskeletal Tumor Society Meeting
  • Place of Presentation: マレーシア
• [Presentation] HOW LONG AND HOW FREQUENTLY SHOULD WE FOLLOW PATIENTS WITH SOFT TISSUE SARCOMAS (2012)
  • Author(s): 澤村 千草
  • Organizer: Musculoskeletal Tumor Society Meeting
  • Place of Presentation: アメリカ タンパ
• [Presentation] Follow Up Strategies for Soft Tissue Sarcoma Patients (2012)
  • Author(s): 澤村 千草
  • Organizer: Connective Tissue Oncology Society
  • Place of Presentation: チェコ
• [Presentation] リンパ節転移のある軟部肉腫患者の長期予後 (2012)
  • Author(s): 澤村 千草
  • Organizer: 日本整形外科学会
  • Place of Presentation: 京都
• [Presentation] Risk of amputation after unplanned excision
  • Author(s): 澤村 千草
  • Organizer: European Musculoskeletal Oncology Society
  • Place of Presentation: ヨーテボリ
• [Presentation] Amputation and additional skin coverage after unplanned excisions of soft tissue sarcomas
  • Author(s): 澤村 千草
  • Organizer: International society of limb salvage
  • Place of Presentation: ボローニャ
• [Presentation] The risk of amputation after unplanned soft tissue sarcoma excisions
  • Author(s): 澤村 千草
  • Organizer: Musculoskeletal Tumor Society Meeting
  • Place of Presentation: サンフランシスコ
• [Presentation] LOCAL RECURRENCE AND OVERALL SURVIVAL AFTER UNPLANNED SOFT TISSUE SARCOMA EXCISIONS
  • Author(s): 澤村 千草
  • Organizer: Connective Tissue Oncology Society
  • Place of Presentation: ニューヨーク