Effects of human bone marrow stromal cell transplantation for microglia in spinal cord injury model mice
| Project/Area Number |
24791530
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Fukui |
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Principal Investigator |
WATANABE Shuji 福井大学, 医学部附属病院, 助教 (00596679)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | spinal cord injury / bone marrow stromal cell / microglia / macrophage / MR16-1 / 脊髄損傷 / 骨髄間質細胞移植 / インターロイキン6受容体抗体 / 細胞生存 / アポトーシス / 骨髄間質細胞 / ミクログリア / 末梢性ベンゾジアゼピン受容体 |
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| Research Abstract |
After BMSC trbone marrow stromal cell(BMSC) treatment, locomotor function was significantly improved in BMSC group. Resident microglia and hematogenous macrophage activation were supressed in chronic state after spinal cord injury. Also, allodynia like behavior was supressed in chronic state after spinal cord injury. So, supression microglia and macrophage has possibility to improve the neuropathic pain after spinal cord injury. In this study, most important problem was the low survival rates of transplanted BMSC. Therefore, we decided to also use anti-IL-6 receptor antibody(MR16-1). With this treatment, the survival rates of BMSC were significantly increased and locomotor function was also improved than BMSC treatment only.
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Report
(3 results)
Research Products
(28 results)
