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Development of novel treatment of rheumatoid arthritis by regulation of adiponectin

Research Project

Project/Area Number 24791542
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionOsaka University

Principal Investigator

EBINA Kosuke  大阪大学, 医学(系)研究科(研究院), 助教 (70612076)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアディポネクチン / 関節リウマチ / プログラニュリン / ApoE
Research Abstract

We established 300 RA patients clinical database including severity and extent of joint destruction. We have previously reported that severity of RA evaluated by the extent of joint destruction is associated with serum adiponectin (APN)levels. In addition, APN and complement C1q forms complex (APN-C1q) in human serum and associate with the risk of cardiovascular events of type2 diabetes. From our results, serum APN-C1q levels of RA patients were significantly higher than that of age-and-BMI matched controls, and also showed stronger correlation with severity and extent of joint destruction compared to serum APN and C1q levels, respectively. Monitoring serum APN-C1q levels may be a novel predictive factor and of RA joint destruction and its clinical application as treatment target is expected.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (50 results)

All 2014 2013 2012

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Open Access: 1 results) Presentation (27 results) Book (5 results)

  • [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility2014

    • Author(s)
      Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, et al
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 11;111(10) Pages: 3787-92

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility2014

    • Author(s)
      Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H
    • Journal Title

      Proceedings of National Academy of Science USA

      Volume: 111 Issue: 10 Pages: 3787-3792

    • DOI

      10.1073/pnas.1401105111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxygen and air nanobubble water solution promote the growth of plants, fishes, and mice2013

    • Author(s)
      Ebina K, Shi K, Hirao M, Hashimoto J, Kawato Y, Kaneshiro S, Morimoto T, Koizumi K, Yoshikawa H
    • Journal Title

      PLoS One

      Volume: 5;8(6)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro2013

    • Author(s)
      Kaneshiro S, Ebina K, Shi K, Hirao M, Hashimoto J, Morimoto T, Koizumi K, Yoshikawa H.
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis2013

    • Author(s)
      Ebina K, Shi K, Hirao M, Kaneshiro K, Morimoto T, Koizumi K, Yoshikawa K, Hashimoto J
    • Journal Title

      ModRheumatol

      Volume: 23(5) Pages: 1001-7

    • NAID

      10031201160

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retention of Tocilizumab and Anti-Tumor Necrosis Factor Drugs in the Treatment of Rheumatoid Arthritis2013

    • Author(s)
      Hishitani Y, Ogata A, Shima Y, Hirano T, Ebina K., et al
    • Journal Title

      Scand J Rheumatol

      Volume: 42(4) Pages: 253-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of gastroesophageal reflux disease symptoms and related factors in patients with rheumatoid arthritis2013

    • Author(s)
      Nampei A, Shi K, Ebina K, Tomita T, Sugamoto K, Yoshikawa H, Hirao M, Hashimoto J
    • Journal Title

      J Clin Biochem Nutr

      Volume: 52(2) Pages: 179-84

    • NAID

      130004466715

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of a custom-made surgical guide in total ankle arthroplasty in rheumatoid arthritis cases2013

    • Author(s)
      Hirao M, Oka K, Ikemoto S, Nakao R, Tsuboi H, Nampei A, Akita S, Shi K, Ebina K, et al
    • Journal Title

      Techniques in Orhopaedics

      Volume: (under publish)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxygen and air nanobubble water solution promote the growth of plants, fishes, and mice.2013

    • Author(s)
      Ebina K, Shi K, Hirao M, Hashimoto J, Kawato Y, Kaneshiro S, Morimoto T, Koizumi K, Yoshikawa H.
    • Journal Title

      PLoS One.

      Volume: 8(6) Issue: 6 Pages: e65339-e65339

    • DOI

      10.1371/journal.pone.0065339

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro.2013

    • Author(s)
      Kaneshiro S, Ebina K, Shi K, Hirao M, Hashimoto J, Morimoto T, Koizumi K,
    • Journal Title

      Journal of Bone and Mineral Metabolism.

      Volume: Epub ahead of print

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of gastroesophageal reflux disease symptoms and related factors in patients with rheumatoid arthritis2013

    • Author(s)
      Nampei A, Shi K, Ebina K, Tomita T, Sugamoto K, Yoshikawa H, Hirao M, Hashimoto J.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 52 Issue: 2 Pages: 179-184

    • DOI

      10.3164/jcbn.12-83

    • NAID

      130004466715

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis.2013

    • Author(s)
      Kosuke Ebina, Kenrin Shi, Makoto Hirao, Shoichi Kaneshiro, Tokimitsu Morimoto, Kota Koizumi, Hideki Yoshikawa, Jun Hashimoto.
    • Journal Title

      Mod Rheumatol.

      Volume: 23(5) Issue: 5 Pages: 1001-7

    • DOI

      10.1007/s10165-012-0789-4

    • NAID

      10031201160

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retention of tocilizumab and anti-tumour necrosis factor drugs in the treatment of rheumatoid arthritis.2013

    • Author(s)
      Hishitani Y, Ogata A, Shima Y, Hirano T, Ebina K, Kunugiza Y, Shi K, Narazaki M, Hagihara K, Tomita T, Yoshikawa H, Tanaka T, Kumanogoh A
    • Journal Title

      Scandinavian Journal of Rheumatology

      Volume: 42 Issue: 4 Pages: 253-259

    • DOI

      10.3109/03009742.2012.762037

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of a custom-made surgical guide in total ankle arthroplasty in rheumatoid arthritis cases.2013

    • Author(s)
      Hirao M, Oka K, Ikemoto S, Nakao R, Tsuboi H, Nampei A, Akita S, Shi K, Ebina K.
    • Journal Title

      Techniques in Orhopaedics.

      Volume: Epub ahead of print

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis2013

    • Author(s)
      Kosuke Ebina
    • Journal Title

      Mod Rheumatol

      Volume: 未

    • NAID

      10031201160

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nkx3.2 promotes primary chondrogenic differentiation by upregulating col2a1 transcription2012

    • Author(s)
      Kawato Y, Hirao M, Ebina K, Shi K, Hashimoto J, Honjo Y, Yoshikawa H, Myoui A.
    • Journal Title

      PLoS One

      Volume: 7(4)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia favors maintenance of the vascular smooth muscle cell phenotype in culture2012

    • Author(s)
      Yamasaki N, Hirao M, Kawato Y, Ebina K, Oze H, Nampei A, Shi K, Yoshikawa H, Hashimoto J
    • Journal Title

      J Biochem Mol Toxicol

      Volume: 26(10) Pages: 381-3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of medium volume and oxygen concentration in the incubator on pericellular oxygen concentration and differentiation of murine chondrogenic cell culture2012

    • Author(s)
      Oze H, Hirao M, Ebina K, Shi K, Kawato Y, Kaneshiro S, Yoshikawa H, Hashimoto J.
    • Journal Title

      In Vitro Cell Dev Biol Anim

      Volume: 48(2) Pages: 123-30

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 脂肪細胞分泌因子アディポネクチン(APN)と補体C1q の複合体(APN-C1q)の血中濃度は非RA 患者よりRA 患者で有意に高値でありかつ破壊関節数による重症度と相関する2014

    • Author(s)
      蛯名耕介, 史賢林, 吉川秀樹
    • Organizer
      第58回日本リウマチ学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 成長因子Progranulin ノックアウトマウスは重度の骨粗鬆症を呈する2014

    • Author(s)
      野口貴明, 蛯名耕介, 史賢林, 吉川秀樹
    • Organizer
      第58回日本リウマチ学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂質運搬蛋白ApolipoproteinE ノックアウトマウスは重度の骨粗鬆症を呈する2014

    • Author(s)
      野口貴明, 蛯名耕介, 史賢林, 吉川秀樹
    • Organizer
      第87回日本整形外科学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 成長因子Progranulin ノックアウトマウスは重度の骨粗鬆症を呈する2014

    • Author(s)
      野口貴明, 蛯名耕介, 史賢林, 吉川秀樹
    • Organizer
      第87回日本整形外科学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪細胞分泌因子アディポネクチン(APN)と補体C1qの複合体(APN-C1q)の血中濃度は非RA患者よりRA患者で有意に高値でありかつ破壊関節数による重症度と相関する2014

    • Author(s)
      蛯名 耕介
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 成長因子Progranulinノックアウトマウスは重度の骨粗鬆症を呈する2014

    • Author(s)
      野口 貴明、 蛯名 耕介
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂質運搬蛋白Apolipoprotein Eノックアウトマウスは重度の骨粗鬆症を呈する2014

    • Author(s)
      野口 貴明、 蛯名 耕介
    • Organizer
      日本整形外科学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Assessment of Time-Dependent Coronal Laxity in Deep Flexion After Posterior-Stabilized Total Knee Arthroplasty2014

    • Author(s)
      Kosuke Ebina
    • Organizer
      2014 ICJR Pan Pacific Orthopaedic Congress
    • Place of Presentation
      Hawaii(アメリカ合衆国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチに伴う骨粗鬆症患者と閉経後骨粗鬆症患者に対する12か月間のテリパラチド20μg連日投与の治療効果の比較検討2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチにおけるエタネルセプトとアダリムマブの一次・二次無効に対するメソトレキセートとステロイドの影響についての検討2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] "関節リウマチ患者の前足部術後の歩行時足底圧分布についての解析2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチ患者においてビタミンK2投与群では非投与群と比較して疾患活動性が有意に低値を示す2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本整形外科学会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 転写因子Nkx3.2は2型コラーゲンとアグリカン転写活性を促進する初期軟骨分化に必須の因子である2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミノドロネート投与前・3カ月後の骨代謝マーカーの推移 ―単剤投与/エルデカルシドール・ビタミンK2併用/ アレンドロネート・リセドロネートからの切り替えでの比較検討-2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本骨粗鬆症学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Influence of concomitant Methotrexate and Prednisolone on drug inefficacy of Etanercept and Adalimumab in patients with rheumatoid arthritis2013

    • Author(s)
      Kosuke Ebina
    • Organizer
      European League Against Rheumatism Congress
    • Place of Presentation
      Madrid(スペイン)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Assessment of plantar pressure distribution during walking after forefoot surgery in patients with rheumatoid arthritis2013

    • Author(s)
      Kosuke Ebina
    • Organizer
      European League Against Rheumatism Congress
    • Place of Presentation
      Madrid(スペイン)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Transcription factor Nkx3.2 plays crucial role in primary chondrogenesis by up-regulating type II collagen a1 transcription activity2013

    • Author(s)
      Kosuke Ebina
    • Organizer
      European Symposium on Calcified Tissues
    • Place of Presentation
      Lisbon(ポルトガル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis2013

    • Author(s)
      Kosuke Ebina
    • Organizer
      European Symposium on Calcified Tissues
    • Place of Presentation
      Lisbon(ポルトガル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチ(RA)に伴う骨粗鬆症患者と閉経後骨粗鬆症患者に対する12か月間のテリパラチド20μg連日投与の治療効果の比較検討2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチ患者においてビタミンK2投与群では非投与群と比較して疾患活動性が有意に低値を示す2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] TKA術後の経時的屈曲位内外反バランスの推移 ~深屈曲位の内側ギャップは術後24カ月で有意に低下する~2013

    • Author(s)
      蛯名 耕介
    • Organizer
      中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチにおけるエタネルセプトとアダリムマブの無効に対するDMARDsとステロイドの影響についての検討2013

    • Author(s)
      蛯名 耕介
    • Organizer
      中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチ前足部術後の足底圧分布についての解析2013

    • Author(s)
      蛯名 耕介
    • Organizer
      中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多発性骨腫瘍様病変を伴った巨大副甲状腺腫瘍摘出後にHungry Bone Syndromeを来した16歳男子の一例2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本骨粗鬆症学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチに伴う骨粗鬆症患者と閉経後骨粗鬆症患者に 対する18か月間のテリパラチド20μg連日投与の 治療効果の比較検討2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本骨粗鬆症学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチ前足部術後の足底圧分布についての解析-中足骨頭の温存が荷重分圧に及ぼす影響について-2013

    • Author(s)
      蛯名 耕介
    • Organizer
      日本足の外科学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチ患者においてビタミンK2投与群では非投与群と比較して血中CRP・MMP-3濃度が有意に低値を示す2012

    • Author(s)
      蛯名 耕介
    • Organizer
      日本リウマチ学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Book] 最新関節リウマチ学2014

    • Author(s)
      蛯名 耕介
    • Total Pages
      5
    • Publisher
      日本臨牀社
    • Related Report
      2013 Annual Research Report
  • [Book] 臨床リウマチ25巻1号2013

    • Author(s)
      蛯名耕介
    • Related Report
      2013 Final Research Report
  • [Book] 生活習慣病改善指導士ハンドブック2013

    • Author(s)
      蛯名 耕介
    • Total Pages
      5
    • Publisher
      コネット
    • Related Report
      2013 Annual Research Report
  • [Book] 臨床リウマチ2013

    • Author(s)
      蛯名 耕介
    • Total Pages
      6
    • Publisher
      日本臨床リウマチ学会
    • Related Report
      2013 Annual Research Report
  • [Book] 臨床リウマチ2013

    • Author(s)
      関節リウマチにおける骨粗鬆症とその治療
    • Total Pages
      6
    • Publisher
      日本臨床リウマチ学会
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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