Development of novel treatment of rheumatoid arthritis by regulation of adiponectin
| Project/Area Number |
24791542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
EBINA Kosuke 大阪大学, 医学(系)研究科(研究院), 助教 (70612076)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アディポネクチン / 関節リウマチ / プログラニュリン / ApoE |
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| Research Abstract |
We established 300 RA patients clinical database including severity and extent of joint destruction. We have previously reported that severity of RA evaluated by the extent of joint destruction is associated with serum adiponectin (APN)levels. In addition, APN and complement C1q forms complex (APN-C1q) in human serum and associate with the risk of cardiovascular events of type2 diabetes. From our results, serum APN-C1q levels of RA patients were significantly higher than that of age-and-BMI matched controls, and also showed stronger correlation with severity and extent of joint destruction compared to serum APN and C1q levels, respectively. Monitoring serum APN-C1q levels may be a novel predictive factor and of RA joint destruction and its clinical application as treatment target is expected.
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility2014
Author(s)
Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H
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Journal Title
Proceedings of National Academy of Science USA
Volume: 111
Issue: 10
Pages: 3787-3792
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oxygen and air nanobubble water solution promote the growth of plants, fishes, and mice2013
Author(s)
Ebina K, Shi K, Hirao M, Hashimoto J, Kawato Y, Kaneshiro S, Morimoto T, Koizumi K, Yoshikawa H
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Oxygen and air nanobubble water solution promote the growth of plants, fishes, and mice.2013
Author(s)
Ebina K, Shi K, Hirao M, Hashimoto J, Kawato Y, Kaneshiro S, Morimoto T, Koizumi K, Yoshikawa H.
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Journal Title
PLoS One.
Volume: 8(6)
Issue: 6
Pages: e65339-e65339
DOI
Related Report
Peer Reviewed
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[Journal Article] Retention of tocilizumab and anti-tumour necrosis factor drugs in the treatment of rheumatoid arthritis.2013
Author(s)
Hishitani Y, Ogata A, Shima Y, Hirano T, Ebina K, Kunugiza Y, Shi K, Narazaki M, Hagihara K, Tomita T, Yoshikawa H, Tanaka T, Kumanogoh A
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Journal Title
Scandinavian Journal of Rheumatology
Volume: 42
Issue: 4
Pages: 253-259
DOI
Related Report
Peer Reviewed
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[Book] 臨床リウマチ2013
Author(s)
関節リウマチにおける骨粗鬆症とその治療
Total Pages
6
Publisher
日本臨床リウマチ学会
Related Report
