Promotion of meniscal healing and regeneration

• Project/Area Number: 24791546
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: FURUMATSU Takayuki 岡山大学, 大学病院, 助教 (20432651)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 半月板 / 半月板修復 / 半月板再生 / 半月板移植 / メカニカルストレス / 転写因子 / 軟骨細胞様形質 / 再生医療 / 遺伝子導入

Outline of Final Research Achievements

The meniscus has several functions such as shock absorption and load distribution by controlling complex biomechanics of the knee joint. Treatments for meniscal injuries still have many clinical issues because of a poor healing status of the meniscus. Our study demonstrated that an appropriate mechanical stress increased the anabolic potential of the meniscus cells. These results will help to promote the healing of meniscal injuries.

Research Products

• [Journal Article] Postoperative change in the length and extrusion of the medial meniscus after anterior cruciate ligament reconstruction. (2015)
  • Author(s): Narazaki S, Furumatsu T, Tanaka T, Fujii M, Miyazawa S, Inoue H, Shimamura Y, Saiga K, Ozaki T.
  • Journal Title: Int Orthop Volume: 0 Pages: 0-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Role of Rho small GTPases in meniscus cells. (2014)
  • Author(s): Kanazawa T, Furumatsu T, Matsumoto-Ogawa E, Maehara A, Ozaki T.
  • Journal Title: J Osthop Res Volume: 32 Issue: 11 Pages: 1479-1486
  • DOI: 10.1002/jor.22703
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ROCK inhibition enhances aggrecan deposition and suppresses matrix metalloproteinase-3 production in human articular chondrocytes. (2014)
  • Author(s): Furumatsu T, Matsumoto-Ogawa E, Tanaka T, Lu Z, Ozaki T
  • Journal Title: Connect Tissue Res Volume: 55 Issue: 2 Pages: 89-95
  • DOI: 10.3109/03008207.2013.852544
  • Peer Reviewed
• [Journal Article] Postoperative change in medial meniscal length in concurrent all-inside meniscus repair with anterior cruciate ligament reconstruction. (2014)
  • Author(s): Furumatsu T, Miyazawa S, Tanaka T, Okada Y, Fujii M, Ozaki T
  • Journal Title: Int Orthop Volume: 00 Pages: 0-0
  • Peer Reviewed
• [Journal Article] Chondromodulin-I derived from the inner meniscus prevents endothelial cell proliferation. (2013)
  • Author(s): Fujii M, Furumatsu T, Yokoyama Y, Kanazawa T, Kajiki Y, Abe N, Ozaki T.
  • Journal Title: J Orthop Res Volume: 31 Issue: 4 Pages: 538-543
  • DOI: 10.1002/jor.22257
  • Peer Reviewed
• [Journal Article] Comparison between normal and loose fragment chondrocytes in proliferation and redifferentiation potential. (2013)
  • Author(s): Sakata K, Furumatsu T, Miyazawa S, Okada Y, Fujii M, Ozaki T.
  • Journal Title: Int Orthop Volume: 37 Issue: 1 Pages: 159-165
  • DOI: 10.1007/s00264-012-1728-x
  • NAID: 120005425668
  • Peer Reviewed
• [Presentation] Cyclic tensile strain stimulates TGF-β-Smad3-dependent expression of CCN2 and COL2A1 in chondrocytic cells. (2014)
  • Author(s): Furumatsu T, Miyazawa S, Tanaka T, Fujii M, Abe N, Ozaki T.
  • Organizer: SICOT TWC
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2014-11-19 – 2014-11-22
• [Presentation] 半月板の形態と機能－細胞生物学的特徴とメカニカルストレスに対する細胞応答－ (2014)
  • Author(s): 古松毅之
  • Organizer: JOSKAS
  • Place of Presentation: 広島市
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] 軟骨様細胞におけるTGF-β-Smad3を介した伸張刺激依存性CCN2・COL2A1発現調節機構の解明 (2014)
  • Author(s): 古松毅之、松本衣未、金澤智子、田中孝明、尾﨑敏文
  • Organizer: 日本軟骨代謝学会
  • Place of Presentation: 京都市
• [Presentation] 半月板inner細胞における周期的伸張刺激を介したSmad3依存性CCN2発現の調節機構 (2013)
  • Author(s): 古松毅之、松本衣未、宮澤慎一、岡田幸正、藤井政孝、田中孝明、呂智超、尾﨑敏文
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 千葉市
• [Presentation] 前十字靭帯再建を伴う半月板縫合術における再鏡視例の検討 (2013)
  • Author(s): 古松毅之、阿部信寛、宮澤慎一、岡田幸正、藤井政孝、尾﨑敏文
  • Organizer: JOSKAS
  • Place of Presentation: 札幌市
• [Presentation] メカニカルストレスによるTGF-βシグナルを介したCCN2発現と半月板細胞の活性化 (2013)
  • Author(s): 古松毅之、金澤智子、宮澤慎一、岡田幸正、藤井政孝、尾﨑敏文
  • Organizer: 日本整形外科学会
  • Place of Presentation: 広島市
• [Presentation] Cyclic tensile strain increases CCN2 expression by inducing Smad3 phosphorylation in human inner meniscus cells. (2013)
  • Author(s): Furumatsu T, Kanazawa T, Ozaki T.
  • Organizer: CORS
  • Place of Presentation: Venice, Italy
• [Presentation] 半月板細胞における周期的伸張刺激を介したSmad3依存性CCN2発現の制御機構 (2013)
  • Author(s): 古松毅之、金澤智子、藤井政孝、松本衣未、三宅由晃、久保田聡、滝川正春、尾﨑敏文
  • Organizer: 日本軟骨代謝学会
  • Place of Presentation: 豊中市
• [Presentation] 半月板inner細胞とouter細胞における軟骨細胞様形質の比較検討 (2012)
  • Author(s): 古松毅之、金澤智子、阿部信寛、宮澤慎一、迫間巧将、井上円加、岡田幸正、小澤正嗣、藤井政孝、松本衣未、尾﨑敏文
  • Organizer: 日整会基礎学術集会
  • Place of Presentation: 名古屋市
• [Presentation] ヒト軟骨様細胞におけるSmad2/3を介した伸張刺激依存性CCN2発現の増加 (2012)
  • Author(s): 古松毅之、小澤正嗣、尾﨑敏文
  • Organizer: 日整会基礎学術集会
  • Place of Presentation: 名古屋市