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Development of a new method for controling longitudinal bone growth by continuous local infusion into the epiphysis

Research Project

Project/Area Number 24791549
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokushima

Principal Investigator

ENISHI Tetsuya  徳島大学, 大学病院, 特任助教 (20467806)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords軟骨 / 骨形成
Outline of Final Research Achievements

The goal of our study is to establish the drug delivery system using local infusion into the epiphysis. Limb length discrepancy was treated with surgery using external fixation and osteotomy. Although limb lengthening resulted in good in clinical, many problems remain such as a long hospitalization.
In this study, we improved the drug delivery system using a micro-infusion pump instead of a osmotic pump. We also succeeded to suppress the long bone growth. Taken together with our previous study, we can control the long bone growth by a continuous local infusion into the epiphysis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2015 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Fracture of a persistent olecranon physis in an adult2015

    • Author(s)
      Tetsuya Enishi, Tetsuya Matsuura, Naoto Suzue, Koichi Sairyo
    • Journal Title

      Trauma case report

      Volume: in press

    • NAID

      120007042444

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Continuous local infusion of insulin-like growth factor-I receptor antagonist into the epiphysis of the rabbit tibia2013

    • Author(s)
      江西 哲也
    • Organizer
      2013 ORS annual meeting
    • Place of Presentation
      Henry B. Gonzalez Convention Center, San antonio, TX, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 脛骨骨端部骨髄腔へのinsulin-like growth factor-I receptor antagonist局所持続注入の効果2012

    • Author(s)
      江西 哲也
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場、愛知県名古屋市
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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