Roles of C-type lectin in the pathogenesis in rheumatoid arthritis.
Project/Area Number |
24791552
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Kyushu University |
Principal Investigator |
OYAMADA Akiko 九州大学, 大学病院, 研究員 (30589461)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | C型レクチン / 関節リウマチ / Mincle |
Outline of Final Research Achievements |
Mincle is a member of C-type lectin. In this study, we examined the involvement of Mincle of synovial macrophage in the pathogenesis of rheumatoid arthritis. Collagen-induced arthritis (CIA) were induced in wild-type (WT) mice and Mincle knockout (Mincle KO) mice. Although Mincle KO mice as well as WT mice developed CIA, the clinical scores of arthritis were lower in Mincle KO mice compared with those of WT mice, indicating that Mincle is involved in the pathogenesis of CIA. When mononuclear cells isolated from peripheral blood (PB) of healthy subjects were incubated with LPS, the expression of Mincle was observed on CD14 cells and the level of Mincle expression depended on the density of LPS. On the other hand, Mincle was not detected on mononuclear cells of PB or synovial membrane from RA patients without stimulation.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Successful in vitro culture of synovial explants from rheumatoid arthritis at the air-liquid interface.2015
Author(s)
Sakuraba K, Fujimura K, Nakashima Y, Okazaki K, Fukushi JI, Ohishi M, Oyamada A, Esaki Y, Miyahara H, Iwamoto Y, Yoshikai Y, Yamada H.
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Journal Title
Arthritis Rheumatol.
Volume: 67
Issue: 4
Pages: 881-892
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 関節リウマチ滑膜組織培養法の開発2014
Author(s)
櫻庭 康司, 藤村 謙次郎, 宮原 寿明, 江崎 幸雄, 中島 康晴, 岡崎 賢, 福士 純一, 大石 正信, 田代 泰隆, 小山田 亜希子, 岩本 幸英, 山田 久方
Organizer
第87回日本整形外科学会学術総会
Place of Presentation
神戸
Year and Date
2014-05-22 – 2014-05-25
Related Report
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[Presentation] 櫻庭 康司, 藤村 謙次郎, 中島 康晴, 岡崎 賢, 福士 純一, 大石 正信, 田代 泰隆, 小山田 亜希子, 橋口 智光, 江崎 幸雄, 宮原 寿明, 岩本 幸英, 吉開 泰信, 山田 久方2014
Author(s)
関節リウマチ滑膜組織培養法の開発
Organizer
第58回日本リウマチ学会総会・学術集会
Place of Presentation
東京
Year and Date
2014-04-24 – 2014-04-26
Related Report
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[Presentation] 難治性の膝関節滑膜炎を来したサルコイドーシスの1例2013
Author(s)
廣瀬毅, 田代泰隆, 山田久方, 井浦国生, 中島康晴, 岡崎賢, 福士純一, 大石正信, 小山田亜希子, 小田義直, 岩本幸英
Organizer
第126回西日本整形・災害外科学会学術集会
Place of Presentation
宇部
Related Report
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