The role of bone marrow adipose tissue on the proliferation, differentiation, and lipotoxicity of osteoblasts
| Project/Area Number |
24791553
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 骨粗鬆症 / 脂肪毒性 / 骨芽細胞 / 骨細胞 / 脂肪組織 / 脂肪細胞 |
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| Research Abstract |
We established a novel cell culture system, which reproduced the transition process from osteoblast to osteocyte. Using this model, we examined the effect of adipose tissue on osteoblasts/osteocytes, and found that 1) adipose tissue inhibit the proliferation and differentiation of osteoblasts by soluble factors, 2) osteocytes were more insensitive to adipose tissue than osteoblasts, and 3) no different effect was observed between subcutaneous and epididymal adipose tissues. These suppressive effects may be involved in the regulatory mechanisms of bone homeostasis.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Phosphaturic mesenchymal tumor, nonphosphaturic variant, causing fatal pulmonary metastasis.2013
Author(s)
Uchihashi K, Nishijima-Matsunobu A, Matsuyama A, Yamasaki F, Tanabe T, Uemura T, Aragane N, Yakushiji M, Yamamoto M, Aoki S, Toda S.
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Journal Title
Human Pathology
Volume: 44
Issue: 11
Pages: 2614-2618
DOI
Related Report
Peer Reviewed
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[Journal Article] 陰茎尿道腺癌の1例2012
Author(s)
松延 亜紀, 薬師寺 舞, 山本 美保子, 内橋 和芳, 青木 茂久, 一倉 晴彦, 戸田 修二, 河野 真司
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Journal Title
診断病理
Volume: 29
Pages: 236-239
NAID
Related Report
Peer Reviewed
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