Analysis of the enhanced bone fudion effect of a new synthetic vitamin E in a rat spinal fusion model.

Research Project

Project/Area Number	24791555
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Orthopaedic surgery
Research Institution	Oita University
Principal Investigator	MIYAZAKI Masashi 大分大学, 医学部, 講師 (30527742)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	BMP / ラット / 脊椎固定 / bisphophonate / Zoledronic acid / マイクロCT / ラット脊椎固定モデル / ラット大腿骨骨折モデル / 骨誘導能 / ビタミンＥ誘導体 / 骨融合
Outline of Final Research Achievements	We aimed to investigate the enhanced effect of bone morphogenetic protein (BMP) and bisphophonate, the enhanced effect of a new synthetic vitamin E and recombinant human BMP-2in a rat spinal fusion model. The synergic effect of a carbon nanofiber and recombinant human BMP-2 The combination of rhBMP-2 and zoledronic acid administered systemically as a single dose at the optimal timewas efficacious in our rat spinal fusionmodel. Our resultssuggest that this combination facilitates spinal fusion and has potential clinical application.

Report

(4 results)