Regulation of development and inflammation through regulating IL-1 expression by Blimp1

• Project/Area Number: 24791561
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: SATO Yuiko 慶應義塾大学, 医学部, 研究員 (70445443)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 骨 / Blimp1 / 炎症 / 成長

Research Abstract

Bone volume is tightly controlled in a delicate balance between bone resorbing osteoclasts and bone forming osteoblasts. This applicant demonstrated that Blimp1 was required to promote osteoclast differentiation, and osteoclast specific Blimp1 conditional knockout mice exhibited significant inhibition of osteoclastogenesis accompanied with significant elevation of bone mass. This applicant also found that conditional inactivation of Blimp1 in cells other than blood cells resulted in significant reduction of bone mass and inflammatory phenotypes.

Research Products

• [Journal Article] HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. (2013)
  • Author(s): Miyauchi Y, Sato Y, Kobayashi T, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Morioka H, Matsumoto M, Chambon P, Johnson RS, Kato S, Toyama Y, Miyamoto T.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 110 Issue: 41 Pages: 16568-16573
  • DOI: 10.1073/pnas.1308755110
  • Peer Reviewed
• [Journal Article] An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion (2012)
  • Author(s): Miyamoto H, Katsuyama E, Miyauchi Y, Hoshi H, Miyamoto K, Sato Y, Kobayashi T, Iwasaki R, Yoshida S, Mori T, Kanagawa H, Fujie A, Hao W, Morioka H, Matsumoto M, Toyama Y, Miyamoto T
  • Journal Title: J Biol Chem Volume: vol. 287 Issue: 39 Pages: 32479-84
  • DOI: 10.1074/jbc.m112.358226
  • Peer Reviewed
• [Journal Article] Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis (2012)
  • Author(s): Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, (他21名)
  • Journal Title: J. Bone Miner Res Volume: 27(9) Issue: 9 Pages: 2015-2023
  • DOI: 10.1002/jbmr.1634
  • Peer Reviewed
• [Journal Article] Conditional inactivation of Blimp1 in adult mice promotes increased bone mass. (2012)
  • Author(s): Miyauchi Y, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W et al.
  • Journal Title: J Biol Chem Volume: 287 Issue: 34 Pages: 28508-28517
  • DOI: 10.1074/jbc.m112.356634
  • Peer Reviewed
• [Journal Article] OC-STAMP and DC-STAMP cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells (2012)
  • Author(s): Miyamoto H, et al
  • Journal Title: J Bone Miner Res Volume: (In press) Issue: 6 Pages: 1289-1297
  • DOI: 10.1002/jbmr.1575
  • Peer Reviewed
• [Journal Article] PDGFBB promotes PDGFRα-positive cell migration into artificial bone in vivo. (2012)
  • Author(s): Yoshida S, Iwasaki R, Kawana H, Miyauchi Y, Hoshi H, Miyamoto H, Mori T, Kanagawa H et al.
  • Journal Title: Biochem Biophys Res Commun. Volume: 421 Issue: 4 Pages: 785-789
  • DOI: 10.1016/j.bbrc.2012.04.084
  • Peer Reviewed
• [Journal Article] An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion. (2012)
  • Author(s): Miyamoto H, Katsuyama E, Miyauchi Y, Hoshi H, Miyamoto K, Sato Y, Kobayashi T, Iwasaki R, Yoshida S, Mori T, Kanagawa H, Fujie A, Hao W, Morioka H, Matsumoto M, Toyama Y, Miyamoto T.
  • Journal Title: J Biol Chem. Volume: 287 Pages: 32479-84
  • Peer Reviewed