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Regulation of development and inflammation through regulating IL-1 expression by Blimp1

Research Project

Project/Area Number 24791561
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

SATO Yuiko  慶應義塾大学, 医学部, 研究員 (70445443)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords骨 / Blimp1 / 炎症 / 成長
Research Abstract

Bone volume is tightly controlled in a delicate balance between bone resorbing osteoclasts and bone forming osteoblasts. This applicant demonstrated that Blimp1 was required to promote osteoclast differentiation, and osteoclast specific Blimp1 conditional knockout mice exhibited significant inhibition of osteoclastogenesis accompanied with significant elevation of bone mass. This applicant also found that conditional inactivation of Blimp1 in cells other than blood cells resulted in significant reduction of bone mass and inflammatory phenotypes.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results)

  • [Journal Article] HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis.2013

    • Author(s)
      Miyauchi Y, Sato Y, Kobayashi T, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Morioka H, Matsumoto M, Chambon P, Johnson RS, Kato S, Toyama Y, Miyamoto T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 110 Issue: 41 Pages: 16568-16573

    • DOI

      10.1073/pnas.1308755110

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion2012

    • Author(s)
      Miyamoto H, Katsuyama E, Miyauchi Y, Hoshi H, Miyamoto K, Sato Y, Kobayashi T, Iwasaki R, Yoshida S, Mori T, Kanagawa H, Fujie A, Hao W, Morioka H, Matsumoto M, Toyama Y, Miyamoto T
    • Journal Title

      J Biol Chem

      Volume: vol. 287 Issue: 39 Pages: 32479-84

    • DOI

      10.1074/jbc.m112.358226

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis2012

    • Author(s)
      Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, (他21名)
    • Journal Title

      J. Bone Miner Res

      Volume: 27(9) Issue: 9 Pages: 2015-2023

    • DOI

      10.1002/jbmr.1634

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Conditional inactivation of Blimp1 in adult mice promotes increased bone mass.2012

    • Author(s)
      Miyauchi Y, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W et al.
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 34 Pages: 28508-28517

    • DOI

      10.1074/jbc.m112.356634

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] OC-STAMP and DC-STAMP cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells2012

    • Author(s)
      Miyamoto H, et al
    • Journal Title

      J Bone Miner Res

      Volume: (In press) Issue: 6 Pages: 1289-1297

    • DOI

      10.1002/jbmr.1575

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] PDGFBB promotes PDGFRα-positive cell migration into artificial bone in vivo.2012

    • Author(s)
      Yoshida S, Iwasaki R, Kawana H, Miyauchi Y, Hoshi H, Miyamoto H, Mori T, Kanagawa H et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 421 Issue: 4 Pages: 785-789

    • DOI

      10.1016/j.bbrc.2012.04.084

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion.2012

    • Author(s)
      Miyamoto H, Katsuyama E, Miyauchi Y, Hoshi H, Miyamoto K, Sato Y, Kobayashi T, Iwasaki R, Yoshida S, Mori T, Kanagawa H, Fujie A, Hao W, Morioka H, Matsumoto M, Toyama Y, Miyamoto T.
    • Journal Title

      J Biol Chem.

      Volume: 287 Pages: 32479-84

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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