| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
To obtain a successful outcome after tendon repair, repaired tendon requires to be anchored biologically to the bone. However, the histological structure at the repaired tendon-bone interface is totally different from that of the normal tendon insertion. This morphological alteration could influence the biological instability after the surgical repair.In this study, we compared the postnatal development at the normal tendon-bone insertion with the repaired supraspinatus tendon-bone insertion in terms of 3D ultrastructure using FIB/SEM tomography, a new scanning electron microscopical method.
Our results identified the difference of the postnatal development of the normal tendon-bone insertion and tendon-bone healing after surgery, additionally, could help better understand the pathophysiology of the tendon-bone insertion. In terms of the clinical perspective, it would contribute to the clue to regenerate the normal insertion at the repaired tendon-bone interface after tendon repair.
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