Electrophysiological analysis of anesthetic neuroprotective effect

Research Project

Project/Area Number	24791582
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Niigata University
Principal Investigator	HONDA Hiroyuki 新潟大学, 医歯学総合病院, 講師 (20535174)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	神経保護 / 脊髄虚血 / パッチクランプ / 興奮性神経細胞死 / ホールセル・パッチクランプ法 / 麻酔薬
Research Abstract	One of the most worrisome complications of thoracoabdominal aneurysm repair is paraplegia caused by spinal cord ischemia. We revealed that ischemic insult induced the three-phase change of synaptic neurotransmission on spinal ventral horn neurons. The reactive oxygen species also produced similar reaction. We also elucidated that mu opioid receptor activation inhibited both the excitatory and inhibitory neurotransmission in spinal ventral horn neurons but did not influence ongoing ischemia-induced neuronal death. Our findings suggest that control of the inhibitory input to the spinal ventral horn neurons is important for neuroprotection.