| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
Epigenetic regulation works through modifying the structures of DNA, making it more or less accessible to transcription. Histone acetylation is one of the types of epigenetic process. In this study, we examined whether histone deacetylase(HDAC) can contribute to sepsis-associated inflammation and apoptosis.
Treatment of novel broad-spectrum HDAC inhibitor suppressed apoptosis induction in lungs and spleens of septic mice. However, it failed to inhibit elevated levels of serum cytokines and prevent lung inflammation in septic mice. Valproic acid also showed antiapoptotic but not anti-inflammatory effects in septic mice.
The data with HDAC inhibitors suggest that imbalance in histone acetylation may play a contributory role in expression or repression of genes involved in septic cell apoptosis.
|
