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Characteristics of spinal dorsal horn neurons responding to mechanical stimulation of bone marrow

Research Project

Project/Area Number 24791587
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology/Resuscitation studies
Research InstitutionShinshu University

Principal Investigator

ISHIDA Takashi  信州大学, 医学部附属病院, 医員 (60531952)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords痛み / 骨 / オピオイド / 脊髄 / 疼痛の発生・増強機構
Research Abstract

We recorded 43 SDH neurons sensitive to balloon inflation in the medullary cavity. Most of the SDH neurons had somatic receptive field at the lower back and the lateral part of thigh. Thirty-two of the SDH neurons were WDR neurons and 11 of the SDH neurons were HT neurons. There were no LT neurons in the 43 SDH neurons tested. Spinally administered morphine (1 microg) did not suppress the responses of the SDH neurons to brush and 4-g von Frey filament but those to pinch and balloon inflation in the medullary cavity. The results suggest that nerve fibers in the medullary cavity sense noxious stimulation and send the signals to SDH. Bone marrow afferent input converges onto the SDH neurons responding to somatic mechanical stimuli. The results supported the concept that activation of bone marrow afferent might lead to the production of referred pain in somatic fields.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results) Book (6 results)

  • [Journal Article] Successful tracheal intubation with the McGrath® MAC video laryngoscope after failure with the Pentax-AWS™ in a patient with cervical spine immobilization2012

    • Author(s)
      Hyuga S, Sekiguchi T, Ishida T, Yamamoto K, Sugiyama Y, Kawamata M
    • Journal Title

      Can J Anaesth 2012

      Volume: 59-12 Pages: 1154-1155

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful tracheal intubation with the McGrath MAC video laryngoscope after failure with the Pentax-AWS in the patient with cervical spine immobilization.2012

    • Author(s)
      Hyuga S, Sekiguchi T, Ishida T, Yamamoto K, Sugiyama Y, Kawamata M.
    • Journal Title

      Can J Anaesth

      Volume: 59 Issue: 12 Pages: 1154-1155

    • DOI

      10.1007/s12630-012-9790-9

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The effect of the TRPV1 antagonist JTS-653 in a rat model of postoperative pain2013

    • Author(s)
      Ishida T, Sakata M, Hamada Y, Matsuo A, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] McGrath® MAC facilitates transesophageal echocardiography probe insertion2013

    • Author(s)
      Takahashi C, Ishida T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Activation of transient receptor potential M8 by cooling and application of menthol can reduce propofol injection-induced pain2013

    • Author(s)
      Watanabe N, Ishida T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect of the TRPV1 antagonist JTS-653 in a rat model of postoperative pain2013

    • Author(s)
      Ishida T, Sakata M, Hamada Y, Matsuo A, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco(America)
    • Related Report
      2013 Annual Research Report
  • [Presentation] McGRATH MAC facilitates transesophageal echocardiography probe insertion2013

    • Author(s)
      Takahashi C, Ishida T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco(America)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Activation o f transient receptor potential M8 by cooling and application of menthol can reduce proposal injection-induced pain2013

    • Author(s)
      Watanabe N, Ishida T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco(America)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Characteristics of spinal dorsal horn neurons responding to mechanical stimulation of bone marrow2012

    • Author(s)
      Ishida T, Tanaka S, Kawamata T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Characteristics of spinal dorsal horn neurons responding to mechanical stimulation of bone marrow2012

    • Author(s)
      Ishida T, Tanaka S, Kawamata T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Washington DC
    • Related Report
      2012 Research-status Report
  • [Presentation] Characteristics of spinal dorsal horn neurons responding to mechanical stimulation of bone marrow2012

    • Author(s)
      Ishida T, Tanaka S, Kawamata T, Kawamata M
    • Organizer
      Annual Meeting of Society for Neuroscience
    • Place of Presentation
      New Orleans
    • Related Report
      2012 Research-status Report
  • [Presentation] 骨髄は痛みを感じるか?2012

    • Author(s)
      石田高志, 田中聡, 川股知之, 川真田樹人
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] 骨髄は痛みを感じるか?2012

    • Author(s)
      石田高志, 田中聡, 川股知之, 川真田樹人
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] Awake Craniotomyにおけるアミノ酸輸液の有用性2012

    • Author(s)
      石田高志, 田中聡, 吉山勇樹, 川真田樹人
    • Organizer
      第10回Awake Surgery研究会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Book] 神経麻酔Q&A エビデンスに基づく最新の知識とテクニック2014

    • Author(s)
      石田高志,川真田樹人
    • Total Pages
      5
    • Publisher
      総合医学社
    • Related Report
      2013 Annual Research Report
  • [Book] 手術後痛とTRPV1. 痛みの Science & Practice 第 1巻. 手術後痛のすべて(川真田樹人編)2013

    • Author(s)
      石田高志, 川真田樹人
    • Publisher
      東京, 文光堂
    • Related Report
      2013 Final Research Report
  • [Book] 術後痛と循環生理. 麻酔科医のための循環管理の実際(新戦略に基づく麻酔・周術期学)(森田潔他編)2013

    • Author(s)
      石田高志, 川真田樹人
    • Publisher
      東京, 中山書店
    • Related Report
      2013 Final Research Report
  • [Book] 神経麻酔 Q&Aエビデンスに基づく最新の知識とテクニック(内野浩之編)2013

    • Author(s)
      石田高志, 川真田樹人
    • Publisher
      東京, 総合医学社
    • Related Report
      2013 Final Research Report
  • [Book] 手術後痛とTRPV1.痛みのScience&Practice 第1巻.手術後鎮痛のすべて2013

    • Author(s)
      石田高志,川真田樹人
    • Total Pages
      2
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report
  • [Book] 術後痛と循環生理.麻酔科医のための循環管理の実際(新戦略に基づく麻酔・周術期学)2013

    • Author(s)
      石田高志,川真田樹人
    • Total Pages
      2
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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