| Project/Area Number |
24791594
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Okayama University (2012, 2014)
National Center of Neurology and Psychiatry (2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 肝移植 / 酸化ストレス / 酸素消費量 |
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| Outline of Final Research Achievements |
We have investigated intra-operative increased oxygen consumption after reperfusion and the mechanism of our results, which reflected higher serum liver enzymes (AST) postoperativel. Thus, we have investigated the relationship between oxidative stress, endothelial cell injury and oxygen consumption. 33 liver transplant recipients (: OLT and 26: LDLT) were eligible for our study. We collected serum Thrombomodulin as the marker of endothelial cell injury and serum CoQ as the marker of oxidative stress at the timings of after-anesthesia induction and one hour after reperfusion. We investigated the relationship between the increased oxygen consumption, endothelial cell injury and oxidative stress between the two groups. This increased oxygen consumption might not be associated with oxidative stress, but instead with endothelial cell injury.
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