neuroprotective effect of remote limb ischemic preconditioning
| Project/Area Number |
24791596
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 四肢虚血リモートプレコンディショニング / early phase / 脳 / 長期保護 / 中大脳動脈閉塞モデル（MCAO） / リモートプレコンディショニング / 四肢虚血 / MCAO / 長期間保護 / 虚血耐性 / ターニケット / レーザードップラー血流計 / 中大脳動脈閉塞 |
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| Outline of Final Research Achievements |
Several studies have shown the beneficial effects of remote limb ischemic preconditioning (RLIP) on brain protection. But there have been few investigations that evaluated its long-term protective effects. The present study examined the neuroprotective effects of RLIP 7 days after reperfusion in a rat focal ischemic model.
there were no physiologically relevant differences among groups for the body weight and all monitored variables. RLIP reduced infarct size (176±79.1 mm3, 62.1±60.0 mm3 ; P=0.003). Neurological score was significantly better in the RLIP group than in the control group (12.2±5.2, 3.4±3.7 at 7 day of reperfusion ; P=0.002).
The present study demonstrates that RLIP induced by noninvasive tourniquet reduces ischemic injury in rats. The protective effects of early phased tolerance were sustained at 7 days. Since RLIP is simple and non-invasive, it has potential for clinical use.
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Report
(4 results)
Research Products
(1 results)
