Reseach of the modulating factors on pharmacological myocardial preconditioning against myocardial ischemia reperfusion injury.
| Project/Area Number |
24791601
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 虚血再灌流 / 心臓 / 心筋プレコンディショニング / 心筋虚血再灌流障害 / 心筋プレコンディションニング |
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| Outline of Final Research Achievements |
The curative therapy for ischemic organ failure is revascularization, whereas the phenomenon termed ischemia-reperfusion(I/R) injury has known to occur at the reperfusion period, and the control of I/R injury could affect patient prognosis. Ischemic or pharmacological preconditioning have known as the powerful means for regulating I/R injury, so we studied about modulating factors on myocardial preconditioning. We hypothesized that clinically used agents such as some anesthetics are modulating factors on myocardial preconditioning, and investigated using myocardial I/R injury rat model.
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Report
(4 results)
Research Products
(4 results)
