The mechanism of insulin resistance induced by the drugs on the perioperative period

Research Project

Project/Area Number	24791603
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology/Resuscitation studies
Research Institution	University of Miyazaki
Principal Investigator	YONAHA Tetsu 宮崎大学, 医学部, 助教 (70468023)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	グルコース / インスリン抵抗性
Research Abstract	Glucose metabolic rate was decreased in sevoflurane treated murine fibroblast-derived adipocytes (3T3L1), suggesting suppressed glucose uptake. In addition, sevoflurane may suppress the translocation of glucose transporter GLUT4 to the cell membrane 3T3L1. Further, the increase of insulin receptor protein, decrease of PKC zeta protein was observed in sevoflurane treated 3T3L1, and are involved in protein expression of pathways involved in glucose transport was suggested.

Report

(3 results)