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Investigation about the sex differences and postoperative nausea and vomiting using epigenome-wide association study.

Research Project

Project/Area Number 24791606
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology/Resuscitation studies
Research InstitutionSapporo Medical University

Principal Investigator

Hayase Tomo  札幌医科大学, 医学部, 助教 (20579007)

Co-Investigator(Renkei-kenkyūsha) YAMAKAGE MICHIAKI  札幌医科大学, 医学部, 教授 (70285005)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords性差 / 麻酔科学 / エピジェネティクス / TACR1遺伝子 / 術後悪心嘔吐 / 国際情報交換
Outline of Final Research Achievements

We investigated whether single nucleotide polymorphisms (SNPs) of the TACR1 gene are associated with postoperative nausea and vomiting (PONV). We found that an SNP within the estrogen response element of the TACR1 gene was strongly associated with decreased frequency of PONV occurrence. Haplotype analysis revealed that patients with a specific haplotype showed lower frequency of PONV occurrence and PONV of less intensity. To determine the association between estrogen and PONV occurrence, we analyzed the methylation rate of the promoter region of the TACR1 gene in humans and investigated whether estrogen promotes the pica behavior in operation model mice. In humans, the intensity of PONV was decreased by methylation of the promoter region of the TACR1 gene. In mice, estrogen and mu-opioid additively promoted pica behavior.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] TACR1 gene polymorphism is associated with gender differences in postoperative nausea and vomiting.2015

    • Author(s)
      Hayase T, Sugino S, Moriya H, Yamakage M.
    • Journal Title

      Anaesthesia

      Volume: 70 Issue: 10 Pages: 1148-1159

    • DOI

      10.1111/anae.13082

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recovery of postoperative cognitive function in elderly patients after a long duration of desflurane anesthesia: a pilot study.2015

    • Author(s)
      Tachibana S, Hayase T, Osuda M, Kazuma S, Yamakage M.
    • Journal Title

      J Anesth

      Volume: epub Issue: 4 Pages: 627-630

    • DOI

      10.1007/s00540-015-1979-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TACR1 gene polymorphism and gender differences in postoperative nausea and vomiting2015

    • Author(s)
      Hayase T, Sugino S, Moriya H, Yamakage M.
    • Journal Title

      Anaesthesia

      Volume: Epub

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy and Safety of a Lidocaine and Ropivacaine Mixture for Scalp Nerve Block and Local Infiltration Anesthesia in Patients Undergoing Awake Craniotomy.2014

    • Author(s)
      Chaki T, Sugino S, Janicki PK, Ishioka Y, Hatakeyama Y, Hayase T, Kaneuchi-Yamashita M, Kohri N, Yamakage M.
    • Journal Title

      J Neurosurg Anesthesiol

      Volume: epub Issue: 1 Pages: 1-5

    • DOI

      10.1097/ana.0000000000000149

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of Generic Sevoflurane by a New Production Process2014

    • Author(s)
      Tomo Hayase, Shigekazu Sugino, Shun-suke Tachibana, Naoyuki Hirata and Michiaki Yamakage
    • Journal Title

      Letters in Drug Design & Discovery

      Volume: 4 Issue: 4 Pages: 495-501

    • DOI

      10.2174/1570180810666131113211447

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Possible mechanism of neuroinflammation induced by surgical procedure in the mouse hippocampus determined by using transcriptome analysis2015

    • Author(s)
      Tachibana S, Hayase T, Yamakage M
    • Organizer
      American society of anesthesiologists annual meeting 2015
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction of the molecular mechanism of postoperative nausea and vomiting using transcriptome analysis2015

    • Author(s)
      Hayase T, Tachibana S, Yamakage M
    • Organizer
      American society of anesthesiologists annual meeting 2015
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estradiol Enhances Female Pica Behavior Through TACR1 Expression in the Caudate Putamen2014

    • Author(s)
      Hayase T, Sugino S, Tachibana S, Yamakage M.
    • Organizer
      The annual meeting of the American Society of Anesthesiologists
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2014-10-11 – 2014-10-15
    • Related Report
      2014 Research-status Report
  • [Presentation] TACR1 Gene Polymorphism Is Associated With Gender Difference in Postoperative Nausea and Vomiting2014

    • Author(s)
      Hayase T, Sugino S, Tachibana S, Yamakage M.
    • Organizer
      The annual meeting of the American Society of Anesthesiologists
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2014-10-11 – 2014-10-15
    • Related Report
      2014 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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