Analysis of synaptic plasticity of the neuropathic pain model

• Project/Area Number: 24791610
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Yokohama City University
• Principal Investigator: MIYAZAKI Tomoyuki 横浜市立大学, 医学部, 助教 (30580724)
• Research Collaborator: KAMIYA Yoshinori 新潟大学, 医学部, 講師 (90381491)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 疼痛 / pCREB / 電気生理 / 脊髄 / 神経可塑性

Research Abstract

SNL induced the elevation of pCREB-staining in lamina2 of spinal dorsal horn, while this change return to basal level 7 days after SNL. This change was true to GAD67-GFP mice. This suggested SNL activated excitatory neurons via the reduction of inhibitory input from GAD67 positive neurons.

Research Products

• [Journal Article] Role of nerve growth factor-tyrosine kinase receptor A signaling in paclitaxel-induced peripheral neuropathy in rats (2014)
  • Author(s): Nakahashi Y, Kamiya Y, Funakoshi K, Miyazaki T, Uchimoto k, Tojo K, Ogawa K, Fukuoka T, Goto T
  • Journal Title: BBRC Volume: 444(3) Pages: 415-9
• [Journal Article] Social isolation perturbs experience-driven synaptic glutamate receptor subunit 4 delivery in the developing rat barrel cortex. (2013)
  • Author(s): Miyazaki T, Kunii M, Jitsuki S, Sano A, Kuroiwa Y, Takahashi T
  • Journal Title: European Journal of Neuroscience. Volume: epub ahead of print Pages: 0-0
  • Peer Reviewed
• [Journal Article] Disrupted cortical function underlies behavior dysfunction due to social isolation. (2012)
  • Author(s): Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takahashi T.
  • Journal Title: Journal of Clinical Investigation. Volume: 122 Pages: 2690-2701
  • Peer Reviewed
• [Journal Article] Developmental AMPA receptor subunit specificity during experience-driven synaptic plasticity in the rat barrel cortex. (2012)
  • Author(s): Miyazaki T, Kunii M, Tada H, Sano A, Kuroiwa Y, Goto T, Malinow R, Takahashi T.
  • Journal Title: Brain Research. Volume: 1435 Pages: 1-7
  • Peer Reviewed
• [Book] The behavior of the Laboratory Rat: A Handbook with Tests (2014)
  • Author(s): 高瀬 堅吉, 宮崎 智之, 他
  • Publisher: 西村書店
• [Remarks] 生理学教室ホームページ
  • URL: http://neurosci.med.yokohama-cu.ac.jp/