Analysis of synaptic plasticity of the neuropathic pain model
| Project/Area Number |
24791610
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Research Collaborator |
KAMIYA Yoshinori 新潟大学, 医学部, 講師 (90381491)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 疼痛 / pCREB / 電気生理 / 脊髄 / 神経可塑性 |
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| Research Abstract |
SNL induced the elevation of pCREB-staining in lamina2 of spinal dorsal horn, while this change return to basal level 7 days after SNL. This change was true to GAD67-GFP mice. This suggested SNL activated excitatory neurons via the reduction of inhibitory input from GAD67 positive neurons.
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Report
(3 results)
Research Products
(6 results)
