| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Tramadol has a multitude of pharmacological properties, acting as an agonist at opioid receptors, while inhibiting reuptake of serotonin and noradrenaline. Combination therapy of tramadol and tricyclic antidepressant may increase serotonin syndrome. Continuous intravenous injection of tramadol resulted in marked increases serotonin concentration in the hypothalamus and induced seizure. Here, we investigated the relationship between serotonin and the seizure-inducing potential of tramadol. Pretreatment significantly affected seizure threshold and serotonin fluctuations. The threshold was lowered in serotonin decreased group and raised in serotonin increased group. So we indicated that tramadol-induced seizures are distinct from serotonin syndrome.
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