Mechanisms of lipid infusion on local anesthetic-induced cardiac toxicity
| Project/Area Number |
24791619
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka City University |
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Principal Investigator |
MATSUURA Tadashi 大阪市立大学, 医学(系)研究科(研究院), 講師 (90619793)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 局所麻酔薬中毒 / 脂肪乳剤 / パッチクランプ / ランゲンドルフ / 局所麻酔薬 / 単離心筋細胞 |
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| Outline of Final Research Achievements |
Lipid emulsion has been reported to be quite effective against local anesthetic-induced systemic toxicity. This study aimed to investigate the mechanisms of lipid infusion therapy. Proton channels recordings by patch-clamp method revealed that extracellular lipid emulsion trapped bupivacaine to decrease the concentration of extracellular bupivacaine and consequently the intracellular concentration of bupivacaine was decreased. This result supports the importance of "lipid sink" of lipid infusion therapy. Both results of lagendorff experiments and in vivo experiments could also suggest that "lipid sink" is the main mechanism of lipid infusion therapy.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] Prediction of left ventricular dysfunction using early diastolic mitral annular velocity after MVR for severe MR
Author(s)
3.Koichi Suehiro, Katsuaki Tanaka, Tadashi Matsuura, Tomoharu Funao, Tokuhiro Yamada, Takashi Mori, Kiyonobu Nishikawa
Organizer
2013 Annual Meeting, American Society of Anesthesiologists
Place of Presentation
Moscone Convention Center, San Francisco, California, USA
Related Report
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[Presentation] Discrepancy between ScvO2 and SvO2 is a reliable index to predict postoperative complications in cardiac surgery
Author(s)
4.Koichi Suehiro, Katsuaki Tanaka, Tadashi Matsuura, Tomoharu Funao, Tokuhiro Yamada, Takashi Mori, Kiyonobu Nishikawa
Organizer
2013 Annual Meeting, American Society of Anesthesiologists
Place of Presentation
Moscone Convention Center, San Francisco, California, USA
Related Report
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