Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Research Abstract |
Repeated oral administration of valproate prevented the development of hypersensitivity in rats after peripheral nerve injury. Intrathecal injection of the selective GLT-1 blocker dihydrokainic acid DHK blocked the effect. This result suggests that valproate prevents the development of chronic pain after peripheral nerve injury in spinal cord in part by preventing downregulation of glutamate transporters. In clinic, we experienced two cases of successful combination therapy by valproate and pregabalin in chronic pain patients. No significant adverse effects are confirmed in the combination therapy. In future, we proceed to the further research to test whether perioperative use of the combination prevents chronic pain after surgery.
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