| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, we focused on the expression change of microRNA(miRNA) under neuropathic pain. The aim of these studies was to clarify the molecular mechanism of chronic pain and to explore the biomarkers of neuropathic pain. Using neuropathic pain model, we were able to profile the expression miRNA in amygdala, nucleus accumbens, prefrontal cortex, spinal cord and serum under neuropathic pain. Furthermore, we identified the change in the serum miRNA in human chronic pain patient. These result suggest that blood miRNA has the potential as a biomarker for neuropathic pain. These research results were published in Trends Neurosci, 38, 237-246, 2015 (IF:12.902), Brain, 136, 828-843, 2013 (IF; 9.457) etc.
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