Mulutiple analysis of miRNA under neuropathic pain
| Project/Area Number |
24791627
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | miRNA / pain / epigentic / Pain / epigenetics / microRNA |
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| Outline of Final Research Achievements |
In this study, we focused on the expression change of microRNA(miRNA) under neuropathic pain. The aim of these studies was to clarify the molecular mechanism of chronic pain and to explore the biomarkers of neuropathic pain. Using neuropathic pain model, we were able to profile the expression miRNA in amygdala, nucleus accumbens, prefrontal cortex, spinal cord and serum under neuropathic pain. Furthermore, we identified the change in the serum miRNA in human chronic pain patient. These result suggest that blood miRNA has the potential as a biomarker for neuropathic pain. These research results were published in Trends Neurosci, 38, 237-246, 2015 (IF:12.902), Brain, 136, 828-843, 2013 (IF; 9.457) etc.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain.2013
Author(s)
Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K, Furuya M, Kobayashi Y, Miyashita K, Okutsu D, Kato A, Nakamura A, Araki A, Omi K, Nakamura M, James Okano H, Okano H, Ando T, Takeshima H, Ushijima T, Kuzumaki N, Suzuki T, Narita M.
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Journal Title
Brain
Volume: 136
Issue: 3
Pages: 828-843
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons.2013
Author(s)
Ito H, Yanase M, Yamashita A, Kitabatake C, Hamada A, Suhara Y, Narita M, Ikegami D, Sakai H, Yamazaki M, Narita M.
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Journal Title
Mol Brain
Volume: 6
Issue: 1
Pages: 59-59
DOI
Related Report
Peer Reviewed
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[Book] 細胞工学2012
Author(s)
池上大悟、山下 哲、落谷孝広、成田 年
Total Pages
4
Publisher
秀潤社
Related Report
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