Antihyperalgesic effect of free radical scavenger in a rat neuropathic pain model.

Research Project

Project/Area Number	24791629
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology/Resuscitation studies
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	NAKAMURA Motohiro 産業医科大学, 医学部, 非常勤医師 (30461578)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	フリーラジカル消去薬 / 神経障害性疼痛 / 行動薬理学 / 鎮痛薬 / 抗侵害作用
Outline of Final Research Achievements	Analgesic effect of free radical scavengers on neuropathic pain was examined using a rat chronic constriction injury model. Systemic and intrathecal administration of 5,5-dimethyl-1-pyrroline N-oxide(DMPO), phenyl N-tert-butylnitrone(PBN) and vitamin E dose-dependently attenuated mechanical and cold hyperalgesia, whereas intracerebroventricular administration of these drugs had no effect on the hyperalgesia. On the other hand, single peritoneal injection of vitamin C or vitamin E after nerve injury did not suppress the development of the neuropathic pain.

Report

(4 results)