• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Antihyperalgesic effect of free radical scavenger in a rat neuropathic pain model.

Research Project

Project/Area Number 24791629
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology/Resuscitation studies
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

NAKAMURA Motohiro  産業医科大学, 医学部, 非常勤医師 (30461578)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsフリーラジカル消去薬 / 神経障害性疼痛 / 行動薬理学 / 鎮痛薬 / 抗侵害作用
Outline of Final Research Achievements

Analgesic effect of free radical scavengers on neuropathic pain was examined using a rat chronic constriction injury model. Systemic and intrathecal administration of 5,5-dimethyl-1-pyrroline N-oxide(DMPO), phenyl N-tert-butylnitrone(PBN) and vitamin E dose-dependently attenuated mechanical and cold hyperalgesia, whereas intracerebroventricular administration of these drugs had no effect on the hyperalgesia. On the other hand, single peritoneal injection of vitamin C or vitamin E after nerve injury did not suppress the development of the neuropathic pain.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Effects of intrathecal and intracerebroventricular administration of luteolin in a rat neuropathic pain model.2014

    • Author(s)
      Hara K, Haranishi Y, Terada T, Takahashi Y, Nakamura M, Sata T
    • Journal Title

      Pharmacol Biochem Behav

      Volume: 125 Pages: 78-84

    • DOI

      10.1016/j.pbb.2014.08.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chlorogenic acid administered intrathecally alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model.2014

    • Author(s)
      Hara K, Haranishi Y, Kataoka K, Takahashi Y, Terada T, Nakamura M, Sata T.
    • Journal Title

      European Journal of Pharmacology

      Volume: 723 Pages: 459-464

    • DOI

      10.1016/j.ejphar.2013.10.046

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi