Antihyperalgesic effect of free radical scavenger in a rat neuropathic pain model.
| Project/Area Number |
24791629
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | フリーラジカル消去薬 / 神経障害性疼痛 / 行動薬理学 / 鎮痛薬 / 抗侵害作用 |
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| Outline of Final Research Achievements |
Analgesic effect of free radical scavengers on neuropathic pain was examined using a rat chronic constriction injury model. Systemic and intrathecal administration of 5,5-dimethyl-1-pyrroline N-oxide(DMPO), phenyl N-tert-butylnitrone(PBN) and vitamin E dose-dependently attenuated mechanical and cold hyperalgesia, whereas intracerebroventricular administration of these drugs had no effect on the hyperalgesia. On the other hand, single peritoneal injection of vitamin C or vitamin E after nerve injury did not suppress the development of the neuropathic pain.
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Report
(4 results)
Research Products
(2 results)
