Ths role of TXNIP-ARRB2 pathway in bladder carcinogenesis
| Project/Area Number |
24791633
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | TXNIP / EMT / E cadherin / Bladder / cancer / BBN / βarrestin2 / Lipid rafts / cavelonin / flotilin |
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| Research Abstract |
Results from the phenotype of BBN induced bladder carcinogenesis model, protein and gene expression analysis of bladder cancer cell lines, and results from protein expression analysis and immunohistochemical study in TXNIP knock out mice. We suggest that TXNIP-ARRB2 pathway related to bladder carcinogenesis, invasion through the expression adjustment of E cadherin.
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Report
(3 results)
Research Products
(1 results)
