Ths role of TXNIP-ARRB2 pathway in bladder carcinogenesis

Research Project

Project/Area Number	24791633
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	University of Tsukuba
Principal Investigator	TAKAOKA Ei-ichiro 筑波大学, 医学医療系, 講師 (50625340)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	TXNIP / EMT / E cadherin / Bladder / cancer / BBN / βarrestin2 / Lipid rafts / cavelonin / flotilin
Research Abstract	Results from the phenotype of BBN induced bladder carcinogenesis model, protein and gene expression analysis of bladder cancer cell lines, and results from protein expression analysis and immunohistochemical study in TXNIP knock out mice. We suggest that TXNIP-ARRB2 pathway related to bladder carcinogenesis, invasion through the expression adjustment of E cadherin.

Report

(3 results)