Analysis of the prostatic hyperplasia mechanism using the three-dimensional image

• Project/Area Number: 24791635
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Chiba University
• Principal Investigator: KAZUYOSHI Nakamura 千葉大学, 医学(系)研究科(研究院), 助教 (50456034)
• Research Collaborator: IGARASHI Tatsuo 千葉大学, フロンティア医工学センター, 教授 (70302544) ; ICHIKAWA Tomohiko 千葉大学, 大学院医学研究院, 教授 (20241953) ; YAMANISHI Tomonori 獨協医科大学, 医学部, 教授 (90220425) ; SAZUKA Tomokazu 千葉大学, 大学院医学研究院, 助教 (90623679)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 医工学 / 排尿 / 泌尿器科学

Outline of Final Research Achievements

There is not the method to evaluate an image about the effects of α 1 blocker which is the representative medicine of the internal use therapeutic drug for patients with prostatic hyperplasia objectively and quantitatively. Even if the thing with the effect of treatment is understood, the mechanism is unknown.Therefore we developed an urinary flow simulation system based on the information obtained from the endoscopic image and, in Chiba University urology department and an engineering graduate course, conducted clinical application for mechanism elucidation. In conducting urinary flow simulation, it led to energy analysis of the urinary flow, and it was recognized that energy efficiency increased in before and after therapy. We were able to confirm the differences using α 1 blocker having different site of action, too.

Research Products

• [Journal Article] Analysis of energy loss mediated by an alpha-1 blocker in patients with benign prostatic hyperplasia using a virtual urethra processed from an endoscopic video image. (2012)
  • Author(s): Sazuka T, Kambara Y, Ishii T, Nakamura K, Sakamoto S, Naya Y, Yamanishi T, Ichikawa T, Igarashi T.
  • Journal Title: Journal of Endourology Volume: 2012 Sep;26(9) Pages: 1216-1220
  • Peer Reviewed
• [Presentation] 尿流動態の画像解析 (2014)
  • Author(s): 仲村和芳
  • Organizer: 第28回日本泌尿器内視鏡学会総会 特別企画
  • Place of Presentation: ヒルトン福岡シーホーク(福岡県福岡市)
  • Year and Date: 2014-11-27
• [Presentation] Critical region responsible for voiding dysfunction locates at midpoint and distal region of the prostatic urethra in BPH patients (2013)
  • Author(s): 仲村和芳
  • Organizer: International continence society 43th Annual meeting
  • Place of Presentation: Barcelona-Spain
• [Presentation] 千葉大学における尿流動態解明に向けての医工連携 (2013)
  • Author(s): 仲村和芳
  • Organizer: 第27回日本泌尿器内視鏡外科学会総会
  • Place of Presentation: 名古屋
• [Presentation] Analysis of energy loss mediated by an alpha-1 blocker in patients with benign prostatic hyperplasia using a virtual urethra processed from an endoscopic video image. (2012)
  • Author(s): 佐塚智和、仲村和芳
  • Organizer: 2nd International Meeting Challenges in Endourology & Functional Urology
  • Place of Presentation: Paris - France