Mechanism of resistance to tyrosine-kinase inhibitor in renal cell carcinoma

• Project/Area Number: 24791654
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kochi University
• Principal Investigator: SHIMAMOTO Tsutomu 高知大学, 医学部附属病院, 医員 (10600794)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 腎細胞癌 / 血管新生 / チロシンキナーゼ阻害剤 / 耐性

Research Abstract

Hyperangiogenesis has not been a role of resistance to tyrosine-kinase inhibitor in renal cell carcinoma. Cross-talk with Hyperangiogenesis and microenvironment might be a key mechanism of resistance to tyrosine-kinase inhibitor in renal cell carcinoma. The resistance has been reversible reaction.
Thus, novel therapeutic strategies are really needed for resolving resistance to tyrosine-kinase inhibitor such as approaching to tumor-microenvironment and combination therapy with others.