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Analysis of the tumor related genes may serves as targets for therapy and construction of predictive models in patients with bladder cancer.

Research Project

Project/Area Number 24791656
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionSapporo Medical University

Principal Investigator

NISHIYAMA Naotaka  札幌医科大学, 医学部, 助教 (70619030)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords膀胱がん / ゲノム網羅的解析 / ADAMTS1 / 尿路上皮癌 / FN1 / HIST1H1C / AKAP12 / GMFG
Research Abstract

In order to clarify genome wide gene expression profiling and copy number alterations in urothelial carcinomas(UCs), array CGH analysis and highly sensitive DNA chip microarrays were performed in UCs obtained from patients and bladder cancer cell lines. Analysis of the data identified cancer related gene ADMTS1 (ADAM metallopeptidase withthrombospondin (TSP) type I motif, 1)which correlated with resistant for chemotherapy with gemcitabine and cisplatin (GC). In the patients with GC, there were significant differnce in progression free survival (p=0.032) and cancer specific survival (p=0.006) between negative and positive ADMTS1 in the immunohitchemistry.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Clinicopathological analysis of patients with non-muscle-invasive bladder cancer: prognostic value and clinical reliability of the 2004 WHO classification system2013

    • Author(s)
      Nishiyama N, Kitamura H, Maeda T, Takahashi S, Masumori N, Hasegawa T, Tsukamoto T
    • Journal Title

      Jpn J Clin Oncol

      Volume: 43 Issue: 11 Pages: 1124-1131

    • DOI

      10.1093/jjco/hyt120

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopapathological analysis of patients with non-muscle-invasive bladder cancer: Prognostic value and clinical reliability of the 2004 WHO classification system2013

    • Author(s)
      Nishiyama N, Kitamura H, Maeda T, Takahashi S, Masumori N, et al.
    • Journal Title

      Japanse Journal of Clinical Oncology

      Volume: 43 Pages: 1124-1131

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological analysis of patients with nonmuscle- invasive bladder cancer who under- went radical cystectomy2012

    • Author(s)
      Nishiyama N, Kitamura H, Mutoh M, Yanase M, Iwaki H, Hasegawa T, Tsukamoto T
    • Journal Title

      Surg Sci

      Volume: 3 Issue: 07 Pages: 347-352

    • DOI

      10.4236/ss.2012.37068

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] BCG failure をきたした筋層非浸潤性膀胱癌の予後に関する後ろ向き・多施設共同研究2013

    • Author(s)
      西山直隆, 進藤哲哉, 堀田裕, 高橋 敦, 柳瀬雅裕, 伊藤直樹, 立木 仁, 宮尾則臣, 松川雅則, 国島康晴, 田口圭介, 北村 寛, 舛森直哉
    • Organizer
      第51回日本癌治療学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinico- pathological analysis of patients with nonmuscle-invasive bladder cancer : Prognostic value and clinical reliability of the WHO grading system of 20042013

    • Author(s)
      Nnishiyama N, Kitamura H, Masumori N, Hasegawa T, Tsukamoto T
    • Organizer
      AUA 2013 Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinicopathological analysis of patients with nonmuscle-invasive bladder cancer: Prognostic value and clinical reliability of the WHO grading system of 20042013

    • Author(s)
      Nishiyama N, Kitamura H, Masumori N, et al.
    • Organizer
      American Urological Association 2013 Annual Meeting
    • Place of Presentation
      San Diego in USA
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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