Analysis of the tumor related genes may serves as targets for therapy and construction of predictive models in patients with bladder cancer.

• Project/Area Number: 24791656
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Sapporo Medical University
• Principal Investigator: NISHIYAMA Naotaka 札幌医科大学, 医学部, 助教 (70619030)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 膀胱がん / ゲノム網羅的解析 / ADAMTS1 / 尿路上皮癌 / FN1 / HIST1H1C / AKAP12 / GMFG

Research Abstract

In order to clarify genome wide gene expression profiling and copy number alterations in urothelial carcinomas(UCs), array CGH analysis and highly sensitive DNA chip microarrays were performed in UCs obtained from patients and bladder cancer cell lines. Analysis of the data identified cancer related gene ADMTS1 (ADAM metallopeptidase withthrombospondin (TSP) type I motif, 1)which correlated with resistant for chemotherapy with gemcitabine and cisplatin (GC). In the patients with GC, there were significant differnce in progression free survival (p=0.032) and cancer specific survival (p=0.006) between negative and positive ADMTS1 in the immunohitchemistry.

Research Products

• [Journal Article] Clinicopathological analysis of patients with non-muscle-invasive bladder cancer: prognostic value and clinical reliability of the 2004 WHO classification system (2013)
  • Author(s): Nishiyama N, Kitamura H, Maeda T, Takahashi S, Masumori N, Hasegawa T, Tsukamoto T
  • Journal Title: Jpn J Clin Oncol Volume: 43 Issue: 11 Pages: 1124-1131
  • DOI: 10.1093/jjco/hyt120
  • Peer Reviewed
• [Journal Article] Clinicopapathological analysis of patients with non-muscle-invasive bladder cancer: Prognostic value and clinical reliability of the 2004 WHO classification system (2013)
  • Author(s): Nishiyama N, Kitamura H, Maeda T, Takahashi S, Masumori N, et al.
  • Journal Title: Japanse Journal of Clinical Oncology Volume: 43 Pages: 1124-1131
  • Peer Reviewed
• [Journal Article] Clinicopathological analysis of patients with nonmuscle- invasive bladder cancer who under- went radical cystectomy (2012)
  • Author(s): Nishiyama N, Kitamura H, Mutoh M, Yanase M, Iwaki H, Hasegawa T, Tsukamoto T
  • Journal Title: Surg Sci Volume: 3 Issue: 07 Pages: 347-352
  • DOI: 10.4236/ss.2012.37068
  • Peer Reviewed
• [Presentation] BCG failure をきたした筋層非浸潤性膀胱癌の予後に関する後ろ向き・多施設共同研究 (2013)
  • Author(s): 西山直隆, 進藤哲哉, 堀田裕, 高橋 敦, 柳瀬雅裕, 伊藤直樹, 立木 仁, 宮尾則臣, 松川雅則, 国島康晴, 田口圭介, 北村 寛, 舛森直哉
  • Organizer: 第51回日本癌治療学会総会
  • Place of Presentation: 京都
• [Presentation] Clinico- pathological analysis of patients with nonmuscle-invasive bladder cancer : Prognostic value and clinical reliability of the WHO grading system of 2004 (2013)
  • Author(s): Nnishiyama N, Kitamura H, Masumori N, Hasegawa T, Tsukamoto T
  • Organizer: AUA 2013 Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] Clinicopathological analysis of patients with nonmuscle-invasive bladder cancer: Prognostic value and clinical reliability of the WHO grading system of 2004 (2013)
  • Author(s): Nishiyama N, Kitamura H, Masumori N, et al.
  • Organizer: American Urological Association 2013 Annual Meeting
  • Place of Presentation: San Diego in USA